Researcher or Senior Researcher - Geeleher Lab - Department of Computational Biology

St. Jude Children's Research Hospital•Memphis, TN

7d•$26 - $46•Onsite

About The Position

The laboratory of Dr. Paul Geeleher (appointments in the Comprehensive Cancer Center, the Graduate School of Biomedical Science, and the Department of Computational Biology) is seeking a wet-lab Researcher or Senior Researcher to support work on mechanistic dissection of hits from high throughput drug and CRISPR screens, the development of new drug combinations, and mechanistic dissection of drug resistance mechanisms in neuroblastoma. Dr. Geeleher’s laboratory tightly integrates wet-bench and computational approaches, aimed at improving outcomes in pediatric cancers, especially neuroblastoma. Our group has spearheaded publications in e.g. Nature, Genome Biology, Journal of the National Cancer Institute (JNCI), and Nature Communications, and is funded by the NIH (R01, R00, R35 awards). We are also closely integrated into the Pediatric Cancer Dependency Map (PedDep), a large multi-institutional collaboration between St. Jude, Dana Farber and the Broad Institute, aimed at discovering new therapeutic targets and drug repurposing opportunities in pediatrics – discoveries that require substantial subsequent work up in the wet-lab. This position is located in Memphis, TN (100% on site position), and relocation assistance is available.

Requirements

Bachelor's degree in relevant scientific area is required.
No experience required (for Researcher position).
Two (2) years of research experience is required with a bachelor's degree (for Senior Researcher position).
No prior experience is required with a Master's degree (for Senior Researcher position).
Working knowledge and understanding of underlying concepts and principles of experimental design (for Senior Researcher position).
Experience with the most widely used techniques used in the home laboratory (for Senior Researcher position).
Proven performance in earlier role/comparable role (for Senior Researcher position).

Nice To Haves

Prior hands-on experience with standard molecular biology techniques such as cell culture, PCR, qPCR/RT-qPCR, DNA and RNA isolation, molecular cloning, transfection and lentiviral transduction, and Western blotting.
An ability to quickly learn and implement new/advanced assays based on research direction is required.
Ability to carefully execute experiments in support of a complex research project is required.
Experience with preclinical models is desirable.
Experience in pediatric cancer, especially neuroblastoma, is desirable but not required.
Familiarity with Microsoft Excel, PowerPoint, and Word software.
Good written and spoken English and presentation / communication skills.
A strong interest in experimental cancer biology and dedication to scientific rigor is essential.

Responsibilities

Supporting complex research projects and contributing to resulting publications.
Performing standard cell and molecular biology assays, with guidance as needed from senior lab members.
Learning and implementing new assays as needed given the research direction.
Supporting a research project and contributing to drafting a manuscript.
Working collaboratively with senior scientists and other lab members.
Perform other related duties as assigned in order to meet the goals and objectives of the department and the institution.
Maintain regular and predictable attendance.