Research Technologist - Sammarco Lab -Limited Tenure

Mayo Clinic•Rochester, MN

2d•Onsite

About The Position

The Sammarco Laboratory in the Department of Orthopedic Surgery at Mayo Clinic is seeking a highly motivated and intellectually engaged Research Technologist to join a growing research program focused on the cellular and molecular mechanisms of musculoskeletal regeneration. Our laboratory seeks to understand how fundamental cellular processes direct regenerative healing, with the long-term goal of translating these discoveries into therapies that improve musculoskeletal repair and functional recovery. Our research integrates molecular biology, regenerative biology, and advanced imaging to investigate several complementary questions in tissue regeneration. Current areas of investigation include how cellular metabolism, mitochondrial homeostasis and remodeling, and reactive oxygen species (ROS) regulate tissue patterning during regeneration of complex musculoskeletal tissues; the mechanisms by which sensory nerves promote bone regeneration; the role of cellular senescence in regenerative healing; and the molecular pathways that distinguish regenerative repair from fibrosis. Together, these studies aim to identify biological mechanisms that can be leveraged to develop innovative regenerative therapies for patients. The successful candidate will join a collaborative, multidisciplinary laboratory committed to scientific rigor, innovation, and continuous learning. We seek an adaptable, detail-oriented individual who enjoys solving challenging scientific problems, learning new technologies, and contributing to the development and optimization of experimental approaches. This position offers opportunities for professional growth, increasing scientific independence, and authorship on peer-reviewed publications based on individual contributions. Candidates who demonstrate initiative, sound scientific judgment, and an interest in advancing laboratory methodologies will be particularly well suited for this position.

Requirements

Bachelor's degree in biology, chemistry, other relevant science, or an associate's degree with 6 years of relevant laboratory experience.
Solid understanding of lab techniques, equipment, and safety.
Ability to organize and carry out laboratory techniques independently and in a team setting.
Experience with basic data analysis.
Demonstrated writing skills.
Proficiency in micropipetting, standard molecular biology techniques, laboratory calculations, and safe wet laboratory practices.

Nice To Haves

Bachelor's degree in biology, molecular biology, biomedical sciences, or a related field.
Previous experience in an academic biomedical research laboratory.
Experience with mammalian cell culture, mouse handling, histology, immunohistochemistry, microscopy, quantitative image analysis, or advanced molecular techniques.
Experience preparing publication-quality figures and contributing to scientific manuscripts.
Exceptional organizational skills.
Meticulous attention to detail.
Excellent written and verbal communication skills.
Ability to manage multiple projects simultaneously.
Ability to adapt to evolving research priorities.
Ability to work effectively both independently and as part of a collaborative, multidisciplinary research team.
Demonstrated commitment to scientific rigor, reproducibility, and continuous learning.

Responsibilities

Perform molecular, cellular, imaging, and animal-based experiments in support of laboratory objectives and sponsored research projects while maintaining rigorous experimental records and ensuring high-quality, reproducible data.
Perform mammalian cell culture, mouse handling and experimental procedures, tissue processing, histological and immunohistochemical assays, microscopy, image acquisition and quantitative image analysis.
Become proficient in core techniques and perform them independently following appropriate training.
Perform standard molecular biology techniques (e.g., qPCR, Western blotting, RNA and DNA isolation, reagent preparation, and other molecular assays).
Conduct data management and basic statistical analyses.
Prepare publication-quality figures and manuscripts.
Present research findings during laboratory meetings.
Contribute to experimental planning, critically evaluate the scientific literature to implement and refine laboratory methods, troubleshoot experimental assays, and assist in the development of new technologies and experimental workflows.
Coordinate equipment and supplies, maintain organized laboratory spaces, standardize workflows, and support collaborations within and outside the laboratory.
Perform routine procedures independently, while more complex studies will be conducted in collaboration with the Principal Investigator and senior laboratory members.