Research Technician III

Children’s Hospital of Philadelphia•Philadelphia, PA

4d•Onsite

About The Position

This role participates in planned research projects by performing research protocols with minimal direction and guidance from the principal investigator, program director or senior scientists. May exercise moderate discretion and judgment in the execution and interpretation of experiments, and of data derived. The laboratories of Amanda Muir, M.D., and Kate Hamilton, Ph.D., at the Children's Hospital of Philadelphia (CHOP) are jointly recruiting a Research Technician. Both laboratories employ an integrated set of tools to investigate gastrointestinal epithelial disease, including mouse models and 3D organoid culture systems — established from both patient-derived and murine tissue — to study disease mechanisms and advance translational research. The Muir Lab focuses on gastrointestinal epithelial diseases including eosinophilic esophagitis (EoE) and Barrett's esophagus. The Hamilton Lab investigates intestinal stem cell biology, inflammatory bowel disease (IBD), and celiac disease.

Requirements

High School Diploma / GED - Required
At least two (2) years of related classroom experience or successful completion of a technical training program (eg. Wistar, WPSI) and research laboratory experience - Required
Advanced understanding of lab procedures, protocols, and equipment.
Intermediate proficiency with lab specific experiments / techniques.
Intermediate scientific analysis skills.
Excellent verbal and written communications skills
Excellent organizational skills
Strong critical thinking / problem-solving skills
Strong analytical skills

Nice To Haves

Bachelor's Degree - Preferred
At least three (3) years of related classroom experience or successful completion of a technical training program (eg. Wistar, WPSI) and research laboratory experience - Preferred

Responsibilities

Performing routine mouse husbandry, health monitoring, and regulatory compliance.
Working with lab manager to coordinate breeding strategies to meet experimental timelines.
Maintaining accurate and up-to-date mouse colony records (breeding records, genotyping logs, cage cards).
Working closely with CHOP's University Laboratory Animal Resources (ULAR) staff, lab manager, and investigators to support colony planning.
Performs research procedures on experimental samples with minimal supervision.
Formulates and performs complex lab experiments and analyzes/ reports the data.
Performs tasks that require knowledge of advanced techniques and lab equipment.
Performs advanced calculations and maintains appropriate log and lab notebooks.
Assists with planning specific research protocols and procedures.
Assists in development & troubleshooting of new techniques and ideas.
May be required to modify scientific methods and protocols (in conjunction with PI).
Checks others' results for completeness and accuracy.
May be responsible for training and mentoring new staff.
May assist in the preparation of grants journal articles, posters and oral presentations.
May perform routine and non-routine tests / experiments as needed.
Maintains office, lab area, reagents, supplies and equipment.
Performs routine maintenance on lab equipment.
Coordinates schedules of tests & procedures.
Attends courses, seminars, and lab meetings to expand knowledge of research and laboratory techniques.
Records results, organizes data and maintains lab notebook in an organized manner.
Conducts literary searches as required.
Supporting molecular biology experiments under the direction of lab investigators.
Maintaining detailed lab notebook and contributing to lab protocols.
Providing support for laboratory infrastructure: keeping workspaces organized and stocked, attending lab meetings, and participating in seminars to broaden scientific knowledge.
The candidate is welcome to develop an independent scientific project — in either lab's area of focus — provided that primary responsibilities are consistently met.
The candidate will have the opportunity to contribute as a co-author on laboratory publications.