Research Technician II- Cheng Lab

Cleveland Clinic•Cleveland, OH

1d•Onsite

About The Position

The Research Technician II will participate in the design, organization, and execution of daily research activities within the Cleveland Clinic Genome Center, directed by Dr. Feixiong Cheng. The role supports experimental research in functional genomics, stem cell-based disease modeling, and molecular biology, including a large portfolio of sponsored projects requiring hands-on work in cell culture, sample preparation, sequencing workflows, and laboratory operations. The position offers exposure to functional genomics and disease modeling and contributes to funded research intended to advance human health and patient care. The position is based at Cleveland Clinic Main Campus in Cleveland and works days, generally 8:30 a.m. to 5:00 p.m., with flexible start and end times. Occasional weekend shifts are required.

Requirements

High school diploma or GED and four years of experience in a research or related laboratory environment; OR an associate degree in laboratory science and three years of experience; OR a bachelor's degree and two years of experience; OR a master's degree and one year of experience.
Ability to perform work in a stationary position for extended periods.
Ability to operate a computer and other office equipment.
Ability to communicate and exchange accurate information.
Ability to distinguish color.
Manual dexterity to handle specimens and repair equipment.
Ability to lift and transport equipment or specimens weighing up to 20 pounds.
May be exposed to hazardous chemicals, bio-hazards, radioactive materials, and similar hazards.
Follow standard precautions and use personal protective equipment as required.

Nice To Haves

Bachelor’s or Master’s degree.
Hands-on experience in cell culture, molecular biology techniques, sample preparation, and laboratory organization.
Comfort executing routine and semi-technical experiments independently.
Strong time management and documentation skills.
Ability to work in a fast-paced research environment.

Responsibilities

Participate in daily research project activities.
Plan, organize, perform, and monitor daily project protocols.
Collect, prepare, and maintain research documentation, including informed consent records, case records, clinical notes, and medical reports.
Report and assist with managing protocol deviations, adverse events, and other project-related issues.
Maintain and upkeep the laboratory.
Order and purchase supplies, gather information on new equipment, and recommend purchases.
Assist with cell culture, including maintenance of iPSC-derived neurons, microglia, astrocytes, and/or brain organoids.
Support functional genomics experiments, including CRISPR/Cas9 or CRISPRi/a workflows, molecular biology techniques such as PCR, cloning, and DNA/RNA extraction, and next-generation sequencing library preparation.
Perform sample processing, reagent preparation, buffer making, and general laboratory organization.
Assist with FACS sample preparation, immunostaining, and microscopy as needed.
Maintain detailed and accurate experimental records in lab notebooks and electronic databases.
Follow standard operating procedures, safety guidelines, and quality control measures.