Research Technician II

New York Genome Center • New York, NY

2d • $46,119 - $58,895 • Onsite

About The Position

The Landau Lab at the New York Genome Center/Weill Cornell Medicine is seeking a highly motivated and detail-oriented experimental scientist to join our interdisciplinary team studying somatic evolution, cancer genomics, and epigenomics. The laboratory develops and applies cutting-edge single-cell, multi-omics, and cell-free DNA technologies to investigate how somatic mutations shape cellular behavior, clonal evolution, and human disease. The successful candidate will contribute to both technology development and biological research projects. The role will involve performing, optimizing, and scaling experimental workflows for next-generation sequencing, single-cell genomics, and functional genomics. The candidate will work closely with experimental scientists, computational biologists, clinicians, and external collaborators to generate high-quality genomic datasets from cultured cells, model systems, and patient-derived samples. This is a primarily wet-laboratory position, although opportunities will be available to participate in sequencing quality control, data interpretation, and the integration of experimental and computational results. The ideal candidate will have a strong foundation in molecular biology, excellent laboratory and organizational skills, and an interest in developing and implementing new genomic technologies. The Landau Lab provides substantial scientific and technical training. This position is particularly well suited for an early-career scientist seeking to develop expertise in experimental genomics and single-cell technologies before pursuing graduate or professional training, although this is not a requirement. The position will primarily be based at Weill Cornell Medicine, with regular interaction and collaboration with teams at the New York Genome Center.

Requirements

• Bachelor’s degree in molecular biology, biotechnology, biochemistry, genetics, genomics, biomedical engineering, or a related discipline;
• Prior hands-on experience in an academic, biotechnology, or clinical molecular biology laboratory;
• Experience with fundamental molecular biology techniques, including DNA and RNA handling, PCR, nucleic acid purification, quantification, and gel or fragment analysis;
• Strong organizational and documentation skills, including the ability to manage multiple samples and experiments simultaneously;
• Ability to follow established protocols while also identifying opportunities for troubleshooting and improvement;
• Strong written and verbal communication skills;
• Demonstrated reliability, initiative, curiosity, and eagerness to learn new technologies.

Nice To Haves

• One or more years of experience with next-generation sequencing library preparation;
• Experience with single-cell genomics, spatial genomics, or other high-throughput molecular assays;
• Experience processing tissues, primary cells, cell suspensions, or isolated nuclei;
• Experience with cell culture, flow cytometry, fluorescence-activated cell sorting, microscopy, or tissue dissociation;
• Familiarity with whole-genome sequencing, RNA sequencing, chromatin accessibility assays, targeted sequencing, or cell-free DNA workflows;
• Experience with assay optimization, protocol development, or systematic troubleshooting;
• Experience using liquid-handling automation, acoustic dispensing, or other high-throughput laboratory instrumentation;
• Basic familiarity with sequencing quality-control metrics or analysis environments such as R, Python, or the command line;
• Master’s degree in a relevant discipline.

Responsibilities

• Perform molecular biology workflows associated with DNA and RNA sequencing, including nucleic acid extraction, sample quality control, amplification, library preparation, purification, quantification, and sequencing submission;
• Process cultured cells, primary specimens, tissues, and cell or nuclei suspensions for genomic and functional assays;
• Perform single-cell and multi-omic workflows, including single-cell RNA sequencing, single-cell ATAC sequencing, combined DNA and RNA profiling, targeted genotyping, and single-cell whole-genome sequencing;
• Contribute to the development, optimization, miniaturization, and scaling of novel experimental methods for single-cell genomics, epigenomics, and cell-free DNA analysis;
• Assist with the implementation of high-throughput and automated laboratory workflows, including liquid-handling and plate-based processes;
• Collaborate with experimental and computational researchers to plan studies, coordinate sample processing, and ensure that generated data address the relevant biological questions;
• Maintain detailed, accurate, and timely records in electronic laboratory notebooks, sample-tracking systems, and project databases;
• Communicate experimental progress, results, and technical issues clearly during project meetings;
• Maintain laboratory organization, reagent inventories, equipment, and appropriate safety practices;
• Support multiple concurrent research and technology-development projects; and
• Perform other responsibilities as assigned.

Benefits

• The pay range for this position is $46,118.80 - $58,895.20. The base salary offered will vary depending on job-related knowledge, skills, experience, education, and the final appointment level.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level