Research Senior Scientist

3316 Takeda Development Center Americas•Boston, MA

5d•Onsite

About The Position

Takeda Development Center Americas, Inc. is seeking a Research Senior Scientist in Cambridge, MA. This role will serve as the DMPK representative on projects supporting gastroenterology, autoimmune, and oncology Drug Discovery Units (DDUs) for developing novel drug therapies. The position involves providing molecular and cellular analysis support, focusing on early drug development and translational research. Key responsibilities include scientific support with a focus on cellular and molecular quantification using cutting-edge technologies like flow cytometry, ddPCR, and Nanostring nCounter. The scientist will communicate project needs, progress, and DMPK deliverables to internal stakeholders. They will also be involved in innovative assay development, troubleshooting bioanalytical assay issues, and identifying/adopting/developing novel technologies to build capabilities and meet project needs in collaboration with DMPK, DDUs, and QPTS groups. The role requires designing, validating, and implementing new methodologies and processes, including in silico approaches, to achieve research goals. The scientist will summarize and present experimental results in cross-functional teams and DMPK meetings. Additionally, they will provide scientific monitoring and guidance to external Contract Research Organizations (CROs) for method transfer, development, troubleshooting, qualification, validation, and reporting to support non-clinical and preclinical development programs, ensuring study conduct, interpreting results, and preparing study reports for internal or regulatory use.

Requirements

Doctorate degree in Pathobiology or related field.
Lead hypothesis-driven investigative research including in vitro, ex vivo and in vivo studies to drive novel therapeutic development including animal handling and biological sample handling.
Design, optimize, and implement molecular, cellular, bioanalytical, and biomarker assays including ELISA, PCR, neutralization assay, proliferation, flow cytometry and ELISPOT to assess transgenes, recombinant proteins, cytokines, antibodies, and immunogenicity for efficacy studies.
Apply advanced computational and statistical approaches to analyze and interpret large, complex datasets to support decisionmaking.
Analyze nucleotide and peptide sequences using bioinformatics or in silico tools to create and evaluate synthetic primers, plasmids, and other synthetic genes and peptides to support therapeutics development.

Responsibilities

Serve as the DMPK representative on projects to support gastroenterology, autoimmune and oncology Drug Discovery Units (DDUs) for developing novel drug therapy by providing molecular and cellular analysis support.
Support early drug development and translational research by providing scientific support with a focus on cellular and molecular quantification using cutting-edge technology, such as flow cytometry, ddPCR, Nanostring nCounter, and other assay platforms.
Communicate with internal stakeholders regarding the project needs, progress updates, and DMPK deliverables.
Perform innovative assay development, trouble-shoot bioanalytical assay related issues, and actively identify/adopt/develop novel technologies for capability building and to meet the ever-changing needs of projects together with key stakeholders in DMPK, different DDUs, and other Quantitative Preclinical and Translational Sciences (QPTS) groups.
Design, validate and implement new methodologies and processes (including in silico approaches) that contribute to the research goals of the group/department.
Summarize and present the experimental results in the cross-functional project teams and DMPK meetings.
Provide scientific monitoring and guidance to external resources (CRO) for the method transfer, development, trouble shooting, qualification, validation and report to support non-/pre-clinical development programs.
Ensure the appropriate conduct of studies, lead the interpretation of study results, and prepare study reports suitable for internal or regulatory use.