Research Scientist I/II: Pharmacology

Novartis•Cambridge, MA

2d•$81,200 - $150,800•Onsite

About The Position

Novartis NIBR Oncology is seeking a lab-based in vivo scientist to join its Oncology Pharmacology team in Cambridge, Massachusetts. The role supports the development and application of in vivo models to evaluate novel cancer therapies and advance the early-stage drug discovery pipeline. Its primary focus is executing in vivo anti-tumor efficacy and pharmacokinetic/pharmacodynamic (PK/PD) studies to evaluate novel drug candidates in CDX, PDX, and syngeneic models. The successful candidate will spend the majority of their time in the lab and contribute within a multidisciplinary, highly matrixed team.

Requirements

For Research Scientist I: BS or MS in biological sciences and at least 2 years of relevant research experience in the pharmaceutical or biotechnology industry.
For Research Scientist II: BS or MS in biological sciences and at least 4 years of relevant research experience in the pharmaceutical or biotechnology industry.
Extensive experience with CDX and PDX xenograft tumor models and/or syngeneic models.
Experience with cell culture.
Hands-on mouse or rat handling, including IV, IP, and PO dosing; tumor implantation; caliper tumor measurements; Xenogen imaging; and blood and tissue collection.
Experience with PCR, ELISA, western blot, and flow cytometry.
Strong analytical, written and verbal communication, and organizational skills.
Proficiency with PowerPoint and commonly used data analysis programs such as Excel and Prism.

Responsibilities

Execute preclinical in vivo studies to explore hypotheses, screen candidate molecules, and establish proof of concept.
Develop in vivo CDX, PDX, and syngeneic models to evaluate anti-tumor activity, PK/PD relationships, and relevant biomarkers of novel compounds in support of clinical development.
Work independently and collaboratively with colleagues in pharmacology to execute studies.
Analyze results critically and present them within a multidisciplinary team environment.
Follow animal protocols and document data and methods carefully in an electronic laboratory notebook.