Scientist/Research Scientist, Molecular Pharmacology (contract position)

Septerna • South San Francisco, CA

11h • $57 - $70 • Onsite

About The Position

Septerna is a biotechnology company focused on developing life-changing medicines for patients, specializing in G protein-coupled receptor (GPCR) drug discovery. The company utilizes its Native Complex Platform™ to recapitulate GPCRs in their native structure, function, and dynamics, enabling advanced drug discovery. Septerna has an emerging pipeline of GPCR-targeted small molecule programs and is seeking passionate and creative individuals to contribute to its mission. The company values diversity of thought, expertise, and background, fostering a collaborative environment where employees can grow, learn, and contribute to discovering new disease-modifying therapeutics. This is a full-time, 12-month contract position based in South San Francisco, CA, focused on advancing Septerna’s Native Complex™ platform by developing quantitative in vitro protein-protein interaction (PPI) assays.

Requirements

• BS with 10+ years of hands-on relevant in vitro pharmacology experience in a biotechnology or pharmaceutical setting, or a PhD in pharmacology, biochemistry, biophysics or related discipline.
• Experience with developing plate-based quantitative protein-protein interaction (PPI) assays as applied to GPCRs or other membrane-protein systems.
• Deep familiarity with state-of-the-art assay methodologies capable of measuring binding interactions and experience applying towards development of robust, well-controlled high throughput assays.
• Experience with complex data analysis and curve fitting using GraphPad Prism.
• Demonstrated experience working collaboratively in a team-oriented environment.
• Clear and effective verbal and written communication skills.

Nice To Haves

• Experience with cell culture, cell engineering and fusion construct design, is a plus.
• Experience with orthogonal binding and biophysical methods, including SPR, co-elution, or pull-down assays, is a plus.

Responsibilities

• Perform as a hands-on assay development scientist working within drug discovery project teams to develop and prosecute novel plate-based displacement binding assays.
• Work collaboratively with Discovery Biology colleagues and our drug discovery project teams to prioritize and advance our science.
• Laboratory notebooking, data analysis and documentation.

Benefits

• The company will not be responsible for any fees related to unsolicited agency resumes.
• Equal Opportunity employer status.
• Participation in the E-Verify program.
• California Consumer Privacy Act Privacy Notice for Job Applicants.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level