Research Scientist

Jazz Pharmaceuticals•Durham, CA

1d•$124,000 - $186,000•Onsite

About The Position

Jazz Pharmaceuticals is a global biopharma company dedicated to developing life-changing medicines for people with serious diseases, often with limited or no therapeutic options. This role is responsible for designing and executing experiments relating to the efficacy and mechanism of action of anticancer compounds, with a specific focus on receptor tyrosine kinases (RTKs), preferably HER2. The position involves documenting and archiving experimental protocols, data, analyses, and conclusions, and contributing to communication of research through publications, presentations, abstracts, and patent applications. This is a self-motivated, full-time, laboratory-based position requiring general supervision and the ability to work on multiple projects.

Requirements

Three or more years of industry or post-doctoral experience in oncology.
Demonstrated expertise in receptor tyrosine kinase biology, preferably including HER2, with experience characterizing RTK signaling, pathway modulation, and therapeutic mechanisms of action.
Experience in oncology and pharmacology assays and techniques.
Exceptional written and verbal communication including publications and conference presentations.
Team player who is highly organized and able to manage multiple concurrent projects with minimal oversight.
Forward-thinking with the ability to anticipate challenges and proactively implement solutions.
Computer proficient.
Experience driving advancement of numerous projects simultaneously.
Ability to identify and initiate tasks, set goals for completion, create timelines, and monitor progress to ensure completion.
Strong sense of urgency to meet business needs.
A positive, "hands-on" approach to the position.
Demonstrated ability to react and respond professionally to changing priorities and timelines.
Demonstrated success in working in a matrix, cross-functional environment.
Demonstrated ability to communicate clearly both written and oral and work independently with a high level of attention to detail.
Ability to perform routine laboratory work, sit or stand at a computer for long stretches of time and type.
Frequently operates a computer and other office productivity machinery, such as a calculator, copy machine, and computer printer.
Occasionally move about inside the office to access file cabinets and office equipment.
May occasionally lift objects up to 25 pounds.

Nice To Haves

Specific focus on receptor tyrosine kinases (RTKs), preferably HER2.
Experience creating stable cell lines with CRISPR and inducible expression.
Experience creating or adapting reporter systems for relevant molecular targets.

Responsibilities

Manage cell culture of cancer and normal cell lines.
Perform in vitro efficacy, mechanism of action, target validation, and biomarker studies with cancer therapeutics, with an emphasis on RTK/HER2-driven models.
Create stable cell lines with CRISPR and inducible expression, including lines engineered to modulate RTK/HER2 signaling.
Create or adapt reporter systems for relevant molecular targets.
Present summary results for internal communications and external presentations.
Support preparation of conference abstracts and manuscripts for publication as needed.
Develop proper operational, data documentation, and troubleshooting procedures.
Perform such other responsibilities and projects that the Company may assign.