Research Scientist, Radiopharmacology

Mariana Oncology•Watertown, MA

5d•$81,200 - $150,800

About The Position

We are seeking an experienced Research Scientist, Radiochemistry to join Mariana’s Radiopharmacology function. This role will support the development of personalized medicine and radiopharmaceuticals through a strong radiochemistry focus, working with project teams to obtain critical data to advance product development. Specifically, this laboratory-based role is responsible for radiolabeling new product candidates, addressing questions developed by the project team. These include agent stability and supporting in vitro and in vivo biodistribution studies. The candidate will also have a role in supporting broader team activities including but not limited to pharmacokinetic studies. The role requires the candidate to analyze data, make presentations at research meetings, and interface productively and successfully with internal cross-functional teams, and potentially external collaborators and contract research organizations (CROs), in addition to contributing to written reports.

Requirements

Bachelor’s Degree in a relevant scientific field, plus 2 – 5+ years’ experience; MS in a relevant scientific field, plus 1+ year of experience
Background in chemistry/radiochemistry
Interest/experience in pharmacology and/or PK research
Strong technical writing and oral communication abilities
Ability to work with computers and software applications, such as Microsoft Office
Ability to work in a small team setting and take on significant responsibilities during daily operations

Nice To Haves

Knowledge in cell culture is desired but not a requirement
Experience working with radioactive material is desired but not a requirement – training will be provided where required
Experience in managing CROs is desired but not required
Radiopharmaceutical experience is desired, but training will be provided for motivated individuals

Responsibilities

Perform radiolabeling, product analysis, and subsequent analyses including product stability
Work closely with other functions to identify necessary studies to drive product advancement
Support in vitro and in vivo radiopharmacology studies by scheduling with Biology, Chemistry, and Pharmacology line functions providing radiolabeled molecules. This will include cell binding and in vitro efficacy studies, as well as in vivo biodistribution and efficacy studies
Follow relevant SOPs, guidelines and policies in a highly regulated environment
Accurately label samples, track collection, and maintain comprehensive records
Follow protocols rigorously and contribute to protocol refinement when needed
Maintain accurate and organized data entry and analysis (including maintaining the Electronic Lab Notebook in an accurate and timely fashion to ensure compliance with internal quality standards) and comply with HSE requirements
Communicate in a time-efficient manner with cross-functional teams in a dynamic research environment
Serve as manager for co-ops and interns; mentor junior associates
Present data to target teams, contribute to written reports and engage with broader company teams
Where necessary, help supporting in vivo studies as required