Research Scientist III; Protein Science

Curia • Buffalo, NY

16h • Onsite

About The Position

The Research Scientist III-Protein Expression & Purification is an integral part of the Curia team, contributing to our success by demonstrating expertise in both the theoretical and practical aspects of protein purification and characterization. The scientist will be able to apply a wide range of biochemistry, analytical and parallel processing techniques to analyze and characterize experimental results, manage internal and external projects, and monitor scientific advances to help recommend and implement improved technology and methods. Effective communication and multitasking skills, and the ability to deliver independent results within a team environment are emphasized.

Curia is a global contract development and manufacturing organization (CDMO) with over 30 years of experience partnering with pharmaceutical and biotech companies to provide life-saving treatments to patients. At Curia, we are on a mission to advance our customers’ therapies from curiosity to cure and ultimately to improve patients’ lives.

Requirements

• Bachelor’s degree with a major in Biology or Biochemistry, and at least five to eight years of relevant experience, or equivalent industrial experience OR Master’s degree with a major in Biology or Biochemistry, and at least three to six years of relevant experience, or equivalent industrial experience OR Ph. D. with a major in Biology or Biochemistry, and at zero to three years of relevant experience, or equivalent industrial experience
• Extensive experience with cell culture and recombinant protein purification
• Must pass a background check
• Must pass a drug screen
• May be required to pass Occupational Health Screening

Nice To Haves

• Prior experience with protein purification systems such as AKTA, NGS, or similar
• Skill of planning and organization of multiple projects simultaneously
• Ability of scientific data presentation and client communication
• Prior experience with molecular cloning and protein analysis
• Prior experience of purification of challenging proteins and troubleshooting skills

Responsibilities

• Conduct protein purification with FPLC including affinity, ion exchange, HIC, etc.
• Conduct protein purification from E. coli, mammalian and/or insect cells.
• Run protein characterization including: HPLC, SDS-PAGE, native PAGE, western blot, DLS, and endotoxin assay.
• Be responsible for cell culture maintenance and transfections including: CHO, HEK 293, Sf9, and Sf21.
• Run molecular cloning including: PCR, DNA digestion, ligation, and mutagenesis.
• Present data (written and/or oral) to clients as necessary.
• Collaborate and provide specific technical expertise to multidisciplinary teams such as assay, cell biology, medicinal chemistry teams (internal and external) for preclinical drug development
• Conduct laboratory operations in a safe manner. Maintain familiarity with the Chemical Hygiene Plan. Exhibit safety awareness and safe work practices
• Follow responsible actions regarding chemical disposal. Maintain compliance with all regulations at the federal, state, and local levels, as well as all appropriate SOPs
• Use and maintain equipment in a neat and orderly manner. Report any malfunction immediately to supervisor. Repair minor problems. Maintain service and calibration records
• Submit complete, documented, and legible reports of testing. Ensure that data is properly filed and accessible for review in accordance with appropriate SOPs
• Recommend and implement methods to increase the quality of products and/or services
• Discuss routinely with supervisor the status of assigned programs and potential problems
• Organize work time so that multiple activities run concurrently. Use time efficiently to accomplish immediate task and perform other needed activities
• Manage workload and time to enable the incumbent to perform multiple projects effectively, and ensure all necessary paperwork is completed on a timely basis
• Participate in self-development activities and training of others

Benefits

• Generous benefit options (eligible first day of employment)
• Paid training, vacation and holidays (vacation accrual begins on first day of employment)
• Career advancement opportunities
• Education reimbursement
• 401K program with matching contributions
• Learning platform

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree