Research Scientist II, Pre-Formulation Chemistry

Novartis•San Diego, CA

1d•Onsite

About The Position

Novartis is seeking a highly motivated individual to join the Chemistry Group and contribute to the development of discovery compounds. This successful candidate will join an energizing and collaborative research environment working in conjunction with cross functional drug discovery teams in providing formulation support for new chemical entities. The ideal candidate must be capable of working independently to execute pre-formulation activities for oligonucleotide drug candidates. As such, strong competency in physical pharmacy and preclinical formulation development is required to efficiently function in this role. The candidate must demonstrate and foster strong team spirit and promote knowledge exchange within and between team, with other departments and functions and 3rd parties, as appropriate.

Requirements

BS in Chemistry or a related discipline, and 1-2 years of directly related industry experience.
Practical experience in developing and preparing preclinical formulations for oligonucleotides, including RNAs and ASO
Basic knowledge of physicochemical properties and their relationship to formulation development
Hands on experience with a range of analytical methods used to assess the properties of oligonucleotide formulations
The ability to manage multiple parallel activities and deliver results to agreed timelines
Ability to work independently and with good English communication skills

Nice To Haves

This is not a PhD-level position.

Responsibilities

Design and develop stage appropriate, fit-for-purpose preclinical formulations for oligonucleotides for delivery via parenteral routes
Basic drug substance characterization by techniques such as XRPD, DSC and TGA, DVS, PLM, DLS, UPLC and MS
Assessment of chemical and physical properties such as solubility, particle size and stability
Characterization of prototype formulations using in vitro tests such as viscosity, aggregation and stability
Preparation of formulations for use in preclinical in vivo studies and authoring protocols describing preparation of formulations for use at internal and external formulation labs
Routine lab support such as buffer and mobile phase preparation, pH meter calibration, and basic troubleshooting of lab equipment
Shipping and receiving of samples between other Novartis and external sites