Research Scientist – Cardiometabolic Therapeutic Area

Amgen • South San Francisco, CA

47d

About The Position

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Scientist – Cardiometabolic Research What you will do Let’s do this. Let’s change the world. In this vital role you will commit to developing a deep understanding of the pathogenic mechanism of cardiometabolic diseases and play a pivotal role in driving our pre-clinical pipeline forward.

Requirements

• Doctorate degree OR Master’s degree and 2 years of biopharmaceutical industry and/or academic laboratory experience OR Bachelor’s degree and 4 years of biopharmaceutical industry and/or academic laboratory experience

Nice To Haves

• Strong expertise in the molecular mechanisms underlying cardiac, cardiovascular, or renal disease biology as demonstrated by high-impact publications in the field.
• Strong organizational skills, a high level of accuracy, commitment to record keeping, and attention to details.
• Extensive hands-on experience handling and performing routine procedures with laboratory rodents, including multiple in vivo dosing routes (IP, PO, SC, IV), diverse blood collection methods (e.g., cardiac, submental), serum/plasma processing, necropsy, perfusion techniques, IVIS imaging, or small rodent survival surgery, with a strong emphasis on animal welfare.
• Ability to perform in vitro assays to dissect the mechanism of action of therapeutic molecules in cultured cells, including primary, immortalized, or iPSC-derived cardiomyocytes, cardiac fibroblasts, immune cells, endothelial cells, and other relevant cardiometabolic cell types
• Experience with 3D engineered cardiac tissue or cardiac/renal organoid models is preferred
• Hands-on expertise with cell line engineering technologies, including CRISPR and lentivirus-, retrovirus-, or piggyBac-based stable cell line generation is preferred

Responsibilities

• Work collaboratively with a team of experts to generate robust data supporting the preclinical validation of novel therapeutic targets or strategies.
• Independently design, execute, and interpret experiments, including troubleshooting, optimization of assays, data collection, interpretation, biostatistical analysis, and presentation.
• Perform a range of procedures in laboratory rodents, such as handling, multi-route dosing, sample collection, and necropsy, followed by ex vivo sample processing and analysis
• Participating in cross-functional drug development teams as a key intellectual and technical contributor

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior