Research Scientist, Biomedical Optics, Levi Lab

UT Southwestern Medical Center•Dallas, TX

1d•Onsite

About The Position

The Levi Laboratory seeks a Research Scientist to lead the development and translational application of optical imaging technologies for objective assessment of skin viability, burn-wound depth, tissue composition, and healing. The laboratory integrates visible, near-infrared (NIR), and short-wave infrared (SWIR) imaging with porcine injury models, human clinical studies, quantitative histology, biostatistics, and machine learning. The successful candidate will design, build, calibrate, operate, and refine multispectral imaging systems; acquire high-quality images in laboratory, animal, operating-room, and clinical environments; develop reproducible image-processing and classification pipelines; and correlate optical measurements with histopathology and clinical assessments. The position requires the ability to bridge optical engineering, tissue optics, image analysis, experimental biology, and clinical translation. A commitment of at least two years is preferred.

Requirements

PhD with major course work in the field of assignment or Master's Degree with major course work in the field of assignment or Bachelor's Degree with major course work in the field of assignment
5 years of research experience in the field of assignment with PhD including 2 years at the level of Senior Research Associate or its equivalent or
7 years of research experience in the field of assignment with Master's degree including 3 years at the level of Senior Research Associate or its equivalent or
9 years of research experience in the field of assignment with Bachelor's degree including 4 years Level of Senior Research Associate or its equivalent.
Advanced training or experience in biomedical optics, optical engineering, biophotonics, spectroscopy, imaging science, biomedical engineering, physics, electrical engineering, computer vision, or a closely related field.
Hands-on experience designing and operating optical imaging or spectroscopy systems, preferably involving SWIR, NIR, multispectral, hyperspectral, or spatial frequency domain imaging.
Knowledge of light-tissue interactions, including wavelength-dependent absorption, scattering, penetration depth, and contrast from water, lipids, collagen, hemoglobin, and melanin.
Proficiency in MATLAB and Python for image processing, quantitative analysis, data visualization, statistical modeling, automation, and reproducible pipeline development.
Experience with camera control, spectral filters, radiometric or reflectance calibration, image registration, region-of-interest analysis, spectral feature extraction, and optical phantom studies.
Experience with biostatistics and predictive-model evaluation, including nonparametric testing, regression, ROC and AUC analysis, cross-validation, and transparent reporting of model limitations.
Excellent scientific judgment, troubleshooting, organization, written and oral communication, collaboration, and project-management skills.
Maintain rigorous, traceable, and reproducible experimental and computational records.
Follow laser and optical safety, electrical safety, biosafety, animal-use, human-subjects, and clinical research requirements.
Maintain a clean, organized, functional workspace and protect sensitive clinical images and data.
Stay current with advances in SWIR detectors, light sources, filters, hyperspectral systems, SFDI, optical-property inversion, fluorescence imaging, computational imaging, and medical-device translation.
Foster a respectful, inclusive, collaborative, and accountable laboratory culture.

Nice To Haves

Experience in large-animal research, human-subjects imaging, burn or wound research, skin biology, histology, or clinical device studies is highly desirable.

Responsibilities

Design, assemble, align, and maintain visible, NIR, multispectral SWIR, or hyperspectral imaging systems using broadband or wavelength-specific sources, diffusers, collimators, dichroic optics, bandpass filters, filter wheels, lenses, apertures, spectrometers, and silicon, germanium, or InGaAs detectors.
Select wavelengths, optical components, acquisition geometry, exposure or integration times, gain, working distance, field of view, spatial resolution, and illumination parameters based on tissue optical properties and the intended biological measurement.
Calibrate imaging systems using reflectance standards, dark and white references, tissue-simulating phantoms, and wavelength-appropriate correction procedures; characterize illumination uniformity, detector response, noise, repeatability, drift, and signal-to-noise ratio.
Develop and execute standardized imaging protocols for tissue phantoms, ex vivo samples, in vivo porcine burn models, and human burn patients, including operating-room workflows that maintain safety, sterility, patient privacy, and minimal disruption to clinical care.
Acquire synchronized visible and SWIR images or videos and accurately document image settings, subject positioning, anatomical location, burn timing, treatment status, calibration data, and relevant environmental variables.
Perform image preprocessing, including bad-pixel and dark-current correction, flat-field or reference normalization, frame averaging, denoising, motion correction, distortion correction, image registration, segmentation, and quality-control review.
Define and track anatomically matched regions of interest across visible images, SWIR wavelength bands, serial time points, surgical markings, biopsies, and histologic sections.
Quantify wavelength-specific and normalized reflectance, spectral ratios or indices, absorption and reduced-scattering parameters, water and lipid sensitivity, spatial heterogeneity, and temporal changes in injured tissue.
Develop and validate statistical and machine-learning approaches for burn-depth classification and treatment-decision support, including feature engineering, training and test separation, cross-validation, receiver operating characteristic analysis, sensitivity, specificity, calibration, uncertainty, and subgroup performance.
Correlate optical measurements with surgeon assessments, operative findings, healing outcomes, and pathology-based burn-depth measurements while explicitly evaluating interobserver disagreement and limitations of each reference standard.
Coordinate tissue collection and histology workflows, including biopsy localization, fixation, paraffin embedding, sectioning, H&E, trichrome and picrosirius red staining, whole-slide scanning, collagen-coagulation or necrosis-depth measurement, and quantitative image analysis.
Perform or supervise porcine research procedures relevant to burn creation, imaging, longitudinal monitoring, tissue collection, and protocol compliance in collaboration with veterinary and surgical personnel.
Write and maintain standard operating procedures, equipment logs, calibration records, code repositories, data dictionaries, and analysis documentation sufficient for reproducibility and future regulatory or device-development activities.
Troubleshoot optical, mechanical, electronic, software, synchronization, and data-quality problems; perform root-cause analysis and implement durable corrective actions.
Prepare publication-quality figures, manuscripts, abstracts, presentations, technical reports, grant applications, and progress reports; present work at laboratory meetings and national or international conferences.
Collaborate with burn surgeons, pathologists, optical engineers, physicists, biomedical engineers, statisticians, computer scientists, industry partners, and regulatory or technology-transfer teams.
Train and supervise junior laboratory personnel in optical-system operation, imaging protocols, image analysis, experimental rigor, safety, and data stewardship.
Plans, organizes coordinates, directs, and personally participates in assigned scientific or medical research project.
Selects or assists in selection of key research personnel.
Determines specific goals or objectives to be attained.
Assigns and reviews work of subordinates.
Plans experimental protocols.
Reviews and analyzes resulting research data.
Revises techniques or approaches to work problems as indicated necessary by research data.
Compiles, writes, and submits research results to supervisor.
Prepares or assists in preparation of research papers, reports, and abstracts for publication as one of co-authors.
Designs, develops, or adapts equipment used in experiments or research to obtain desired results.
Plans and supervises training of technicians and other laboratory personnel with respect to proper laboratory techniques, use of laboratory equipment, and safety procedures.
Supervises group of employees of lower grade engaged in performance of technical and professional work, which vary from routine to complex laboratory work tasks.
May confer with industrial, governmental, or other groups concerning progress or results of research project.
Performs other duties as assigned.

Benefits

PPO medical plan, available day one at no cost for full-time employee-only coverage
100%25 coverage for preventive healthcare-no copay
Paid Time Off, available day one
Retirement Programs through the Teacher Retirement System of Texas (TRS)
Paid Parental Leave Benefit
Wellness programs
Tuition Reimbursement
Public Service Loan Forgiveness (PSLF) Qualified Employer
healthcare
PTO and paid holidays
on-site childcare
wage, merit increases