Research Lab Technician I

Mass General Brigham•Boston, MA

8d•Onsite

About The Position

Under general supervision of the Principal Investigator and in accordance with established hospital policies and procedures, provides technical support for research involving the development and application of ultrasensitive biomarker detection technologies. Performs laboratory experiments, documents experimental results, and analyzes data using appropriate statistical methods. A position is open for a full-time Research Assistant in the Department of Pathology at Brigham and Women’s Hospital. The laboratory develops and applies ultrasensitive protein detection technologies, including single molecule array (Simoa) and Molecular On-bead Signal Amplification for Individual Counting (MOSAIC), for biomarker detection and diagnostic applications. The candidate will develop, optimize, and perform ultrasensitive single- and multiplex protein assays to measure low-abundance biomarkers in human biofluids. Specific applications may include cancer biomarker detection and validation, early disease detection, treatment-response monitoring, and other diagnostic applications. The candidate will work independently, under general supervision, to perform experiments, optimize assay performance, analyze data, and measure biomarkers that may be undetectable using conventional methods. Research conducted by the candidate in collaboration with the research team will contribute to the development of new diagnostic technologies and address underlying biological questions. The position will also provide opportunities to interact and collaborate within the broader Harvard Medical School and Wyss Institute for Biologically Inspired Engineering research environments.

Requirements

BA/BS in biological, chemical, physical, or related science required.
Prior laboratory experience, either through academic coursework, internships, or employment 1-2 years preferred
Sound analytical and organizational skills
High degree of computer literacy.
Requires good oral and written communication skills
Ability to logically and effectively structure tasks and set priorities
Ability to identify potential problems and trouble-shoot solutions.
Ability to accurately document, analyze, and interpret experimental data.
Ability to work both independently and collaboratively in a multidisciplinary research environment.
Strong attention to detail and ability to perform quantitative laboratory procedures accurately.

Nice To Haves

Can this role accept experience in lieu of a degree? Yes

Responsibilities

Independently performs routine and non-routine experiments of moderate to high complexity. Experimental work may include preparing reagents, conjugating and evaluating antibodies and other binding reagents, developing and optimizing Simoa and MOSAIC assays, generating calibration curves, performing single- and multiplex biomarker measurements in human biofluids, evaluating assay performance, and troubleshooting experimental procedures.
Calculates, transcribes, and analyzes data using moderate to advanced statistical techniques.
Performs literature searches, prepares presentations and progress reports, and assists in preparing manuscripts for publication. Corresponds and communicates progress professionally with collaborators and scientific community.
In collaboration with PI or Research Manager, establishes new and modifies existing research techniques.
Coordinates schedule of tests and procedures. Documents experimental work accurately and in detail.
Coordinates lab activities such as bio-safety trainings.
Assists in the orientation and training of new staff.
Ordering and inventory of laboratory supplies.