Research Lab Technician I

Mass General Brigham•Boston, MA

2d•Onsite

About The Position

The Miller Laboratory at the Massachusetts General Hospital Center for Systems Biology is recruiting a full-time Research Technician. The Miller Laboratory for Precision Therapeutics develops new chemical and nanotechnology-based approaches for spatially controlled cancer therapy. Our research combines organic synthesis, bioconjugate chemistry, drug delivery, molecular imaging, cancer biology, immunology, and quantitative tissue analysis to understand and engineer how therapeutics behave within tumors. The successful candidate will collaborate with postdocs and faculty on projects involving radiation-activated chemistry, drug conjugates, and externally triggered therapeutic systems. Research may include the testing and purification of radiation-responsive linkers and prodrugs; development and synthesis of antibody, protein, polymer, or nanoparticle conjugates; investigation of radiation-mediated payload activation; and characterization of new compounds using cell culture assays, mouse tumor models, and microscopy. Projects may also incorporate radiopharmaceuticals, ultrasound-responsive drug delivery, bioorthogonal chemistry, molecular imaging, and studies of the tumor immune microenvironment. Therapeutic distribution and response may be evaluated using preclinical tumor models, multiplex tissue imaging, flow cytometry, single-cell analysis, and spatial-omics techniques. The technician will work within a multidisciplinary environment and collaborate with chemists, cancer biologists, immunologists, engineers, imaging scientists, radiation oncologists, and other physician-scientists across Massachusetts General Hospital and the broader Harvard research community.

Requirements

Bachelor's Degree in a Related Field of Study required.
Prior laboratory experience, either through academic coursework, internships, or employment (1-2 years preferred).
Strong theoretical and practical knowledge of laboratory techniques and procedures.
Familiarity with common laboratory equipment and instruments used in research experiments.
Proficiency in data collection, analysis, and scientific software tools.
Excellent attention to detail, organizational skills, and the ability to multitask and prioritize tasks effectively.
Strong problem-solving skills and the ability to troubleshoot technical issues.
Excellent written and verbal communication skills to effectively convey experimental procedures, results, and challenges.

Responsibilities

Perform laboratory experiments following established protocols and procedures.
Prepare and handle samples, reagents, and solutions, ensuring accuracy and adherence to safety guidelines.
Operate and maintain laboratory equipment and instruments, conducting routine calibration and troubleshooting as needed.
Record experimental data accurately and maintain organized records of procedures, protocols, and results.
Compile and analyze data using appropriate statistical and analytical methods.
Assist in data interpretation and presentation, contributing to research findings and reports.