Research Lab Tech I, Pathology

Mass General Brigham • Boston, MA

1d • Onsite

About The Position

Join the Santagata Lab at Brigham and Women’s Hospital (BWH) as a Technical Research Assistant I. This role involves using cutting-edge molecular tissue imaging and quantitative assay methods to study tumor development, therapy resistance, and disease mechanisms in patient samples across various cancers. It offers an opportunity to work at the interface of biological chemistry, molecular imaging, and clinical research, contributing to the development of new cancer therapies and diagnostics. The position is based in Dr. Sandro Santagata’s laboratory and involves close collaboration with Dr. Peter Sorger’s multidisciplinary team at Harvard Medical School’s (HMS) Laboratory of Systems Pharmacology (LSP), as well as members of Ludwig Cancer Research, the David Liposarcoma Research Initiative, the Bertarelli Rare Cancer Initiative, and the Pituitary Neuroendocrine Tumor Translational Research (BioPitNeT). The successful candidate will engage with a vibrant network of scientists, physicians, chemists, and computational biologists across institutions including BWH, HMS, Massachusetts General Hospital, Dana-Farber Cancer Institute, Boston Children’s Hospital, and the Ludwig Center at Harvard, as well as nationwide collaborators. This role directly contributes to research informing innovative clinical trials for immunotherapy and targeted therapies for sarcomas, gliomas, carcinomas, and neuroendocrine-related tumors, and involves investigating disease mechanisms and pharmacodynamics (PD) to support biomarker and drug development. Opportunities are also available to participate in studies of pulmonary and renal diseases. This is a chance to be part of a dynamic, multidisciplinary team at the forefront of quantitative biology and translational pathology, gaining hands-on experience with high-dimensional pathology imaging, molecular assay development, data processing, computational analysis, and visualization, while contributing to high-impact translational research.

Requirements

• Bachelor’s degree in a quantitative discipline, such as chemistry, biological chemistry, chemical biology, biophysics, biomedical engineering, or a related field
• Demonstrated interest in biomedical research, molecular measurement, and human disease
• Willingness to commit to a two-year position and grow in a dynamic research environment
• Strong background in biochemistry or biological chemistry, including understanding of protein structure–function relationships, antibody–antigen interactions, and molecular binding principles, is important for the design, optimization, and interpretation of multiplexed tissue imaging assays
• Strong communication skills and the ability to work both independently and collaboratively within a multidisciplinary research team

Nice To Haves

• Experience or strong interest in microscopy, molecular or biochemical assays, quantitative biology, or data analysis is highly valued
• Familiarity with or interest in quantitative image analysis and data science tools (e.g., Python, R, MATLAB, ImageJ) is preferred

Responsibilities

• Use cutting-edge molecular tissue imaging and quantitative assay methods to study tumor development, therapy resistance, and disease mechanisms in patient samples across a range of cancers
• Contribute directly to research that informs innovative clinical trials for immunotherapy and targeted therapies for sarcomas, gliomas, carcinomas, and neuroendocrine-related tumors
• Investigate disease mechanisms and pharmacodynamics (PD) to support biomarker and drug development
• Participate in studies of pulmonary and renal diseases
• Perform high-dimensional pathology imaging, molecular assay development, data processing, computational analysis, and visualization

Benefits

• Comprehensive benefits
• Career advancement opportunities
• Differentials
• Premiums
• Bonuses
• Recognition programs designed to celebrate your contributions and support your professional growth

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Number of Employees: 5,001-10,000 employees