Research Fellow- PC - Ophthalmology - Marmorstein lab

Mayo Clinic • Rochester, MN

2d • Onsite

About The Position

The Retinal Regenerative Medicine Laboratory at Mayo Clinic in the Department of Ophthalmology is seeking a highly motivated postdoctoral fellow to assist in the development of a novel approach to retinal gene therapy incorporating fibrin-hydrogel encapsulated AAV vectors. The candidate will be part of a team focused on the translation to the clinic of this novel approach with the goal of submitting an IND application. The successful candidate will work as part of a team dedicated to GMP process development for manufacture, storage/stability, testing, and shipping of fibrin-encapsulated AAV. This involves design, testing, and qualification of hydrogel formulation, in-process testing, and release assays, in vivo testing, as well as preparation of regulatory filings and technology transfer to external CROs/CDMOs.

Requirements

• MD/PhD or PhD in a biological science
• Excellent record keeping skills
• Excellent manuscript writing skills
• Excellent presentation skills
• Excellent scientific communication skills

Nice To Haves

• Experience with cell culture
• Experience with cell-based assays
• Experience with hydrogels
• Experience with immunofluorescence
• Experience with gene therapy
• Experience with molecular biology
• Prior experience in ophthalmic research

Responsibilities

• Assist in the development of a novel approach to retinal gene therapy incorporating fibrin-hydrogel encapsulated AAV vectors.
• Work as part of a team dedicated to GMP process development for manufacture, storage/stability, testing, and shipping of fibrin-encapsulated AAV.
• Design, test, and qualify hydrogel formulation.
• Perform in-process testing and release assays.
• Conduct in vivo testing.
• Prepare regulatory filings.
• Facilitate technology transfer to external CROs/CDMOs.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree