Research Fellow- PC - Ophthalmology - Marmorstein lab

Mayo Clinic•Rochester, MN

12h•$67,282 - $78,711•Onsite

About The Position

The Retinal Regenerative Medicine Laboratory at Mayo Clinic in the Department of Ophthalmology is seeking a highly motivated postdoctoral fellow to assist in development of a novel approach to retinal gene therapy incorporating fibrin-hydrogel encapsulated AAV vectors. The candidate will be part of a team focused on translation to the clinic of this novel approach with the goal of submitting an IND application. The successful candidate will work as part of a team dedicated to GMP process development for manufacture, storage/stability, testing, and shipping of fibrin-encapsulated AAV. This involves design, testing, and qualification of hydrogel formulation, in-process testing, and release assays, in vivo testing, as well as preparation of regulatory filings and technology transfer to external CROs/CDMOs.

Requirements

Highly motivated postdoctoral fellow
Experience with AAV vectors
Experience with hydrogel formulation
Experience with in vivo testing
Experience with regulatory filings
Experience with technology transfer

Responsibilities

Assist in development of a novel approach to retinal gene therapy incorporating fibrin-hydrogel encapsulated AAV vectors.
Work as part of a team focused on translation to the clinic of a novel approach to retinal gene therapy.
Work as part of a team dedicated to GMP process development for manufacture, storage/stability, testing, and shipping of fibrin-encapsulated AAV.
Design, testing, and qualification of hydrogel formulation.
Perform in-process testing and release assays.
Conduct in vivo testing.
Prepare regulatory filings.
Facilitate technology transfer to external CROs/CDMOs.