Research Fellow-Neuroscience-Fiesel lab
About The Position
Postdoctoral research positions are available in the laboratory of Dr. Fabienne Fiesel to investigate pathogenic mechanisms of neurodegeneration at Mayo Clinic in Jacksonville, Florida. The Fiesel lab studies molecular pathways that regulate tau biology and protein homeostasis, with a particular interest in UFMylation and how alterations therein contribute to Alzheimer’s disease and related neurodegenerative disorders. The lab employs a multi-disciplinary approach using state-of-the-art techniques in cell biology, biochemistry, imaging, and proteomics to illuminate the underlying disease biology in iPSC-derived cell models, in vivo in mice, and in human clinical and neuropathological specimens. Specific research projects include 1) investigation of mechanisms regulating tau aggregation and propagation in Alzheimer’s disease and related tauopathies, 2) identification of UFM1-modified proteins and pathways using biochemical and proteomic approaches, 3) mechanistic studies of tau and UFMylation in iPSC-derived cells and mouse models, as well as 4) genetic and pharmacological modulation of UFMylation as a potential therapeutic strategy.
Requirements
- Recent Ph.D. or M.D./Ph.D.
- Strong research background in neuroscience, cell biology, or biochemistry.
- Record of impactful, peer-reviewed publications.
- Excellent verbal and written communication skills in English.
Nice To Haves
- Expertise in iPSC models.
- Expertise in mouse work.
- Expertise in imaging approaches.
- Expertise in proteomics approaches.
Responsibilities
- Investigate pathogenic mechanisms of neurodegeneration.
- Study molecular pathways that regulate tau biology and protein homeostasis.
- Investigate UFMylation and its role in Alzheimer's disease and related neurodegenerative disorders.
- Employ multi-disciplinary approaches using cell biology, biochemistry, imaging, and proteomics.
- Illuminate underlying disease biology in iPSC-derived cell models, in vivo in mice, and in human clinical and neuropathological specimens.
- Investigate mechanisms regulating tau aggregation and propagation in Alzheimer’s disease and related tauopathies.
- Identify UFM1-modified proteins and pathways using biochemical and proteomic approaches.
- Conduct mechanistic studies of tau and UFMylation in iPSC-derived cells and mouse models.
- Explore genetic and pharmacological modulation of UFMylation as a potential therapeutic strategy.
Benefits
- Competitive stipend
- Generous fringe benefit package
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
