Research Associate – RNA

SeqMatic LLC. • Fremont, CA

2d

About The Position

SeqMatic is hiring a Research Associate to join its single cell sequencing services team. The position requires a strong background in molecular biology, particularly nucleic acid purification and next-generation sequencing (NGS) and omics workflows. The role involves accessioning, tracking, processing, and organizing customer samples; extracting and purifying RNA from diverse biological specimens; assessing RNA quality; and preparing bulk RNA sequencing libraries using commercial and custom workflows. The Research Associate will also operate laboratory equipment, maintain detailed experimental records, contribute to process optimization and new workflow implementation, troubleshoot technical issues, and communicate with customers and internal team members about project status and technical matters.

Requirements

• Bachelor's degree in Molecular Biology, Cell Biology, Biochemistry, Genetics, Biotechnology, or a related life science field.
• At least 2 years of hands-on molecular biology laboratory experience.
• At least 2 years of experience performing RNA extraction and purification from a variety of biological sample types.
• At least 2 years of experience preparing next-generation sequencing libraries, preferably RNA sequencing libraries.
• Experience assessing RNA quality using Agilent TapeStation, Bioanalyzer, Qubit, NanoDrop, or equivalent platforms.
• Experience with Illumina-based NGS workflows and library preparation kits.
• Familiarity with RNA-seq methods including mRNA-seq, total RNA-seq, small RNA-seq, and low-input RNA applications.
• Strong attention to detail and commitment to generating high-quality data.
• Excellent organizational, analytical, and troubleshooting skills.
• Solid verbal and written English communication skills.
• Ability to manage multiple projects simultaneously and perform effectively in a fast-paced environment.
• Ability to work independently and collaboratively within a team environment.
• Must be legally authorized to work in the United States.

Nice To Haves

• Experience working with FFPE samples.
• Experience with laboratory automation platforms such as Beckman Coulter, Hamilton, Agilent Bravo, or Opentrons.

Responsibilities

• Accession and track samples using LIMS.
• Receive, process, and organize customer samples while maintaining chain of custody and sample integrity.
• Extract and purify total RNA from FFPE and fresh frozen tissues, blood, PBMCs, cultured cells, and other biological specimens.
• Perform RNA quality control using instruments such as Agilent TapeStation, Bioanalyzer, NanoDrop, and Qubit.
• Prepare bulk RNA sequencing libraries using commercial and custom workflows, including poly(A) selection, rRNA depletion, stranded total RNA-seq, mRNA-seq, and small RNA library preparation methods.
• Operate laboratory equipment, including thermocyclers, qPCR systems, automated liquid handlers, and benchtop centrifuges.
• Maintain detailed experimental records in accordance with laboratory procedures and quality standards.
• Assist with process optimization, troubleshooting, technology evaluations, and implementation of new RNA-seq workflows.
• Communicate with customers and internal team members regarding project status and technical issues.

Benefits

• Competitive salary
• Bonus
• 401(k) matching
• Company lunch program
• Medical, dental, and vision benefits

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level