Research Associate/Senior Research Associate, Protein Engineering

Systimmune•Redmond, WA

7d•$60,000 - $85,000•Onsite

About The Position

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success. We are seeking a skilled Research Associate/Senior Research Associate with experience in utilizing display technologies (yeast/phage) in protein engineering, directed evolution, or binder discovery. This is a laboratory-based role that will be supporting protein engineering efforts in discovering novel binders and novel protein leads/scaffolds. The position will join a growing protein engineering team in an innovative organization and reports to the Director of Protein Engineering. The ideal candidate will be a quick learner with a broad experience set with direct expertise in a display technology and/or an adjacent field including but not limited to high throughput molecular biology, antibody/binder discovery, and protein engineering. Industry experience in biologics drug development is required.

Requirements

BS or MS in immunology, biochemistry, molecular biology, structural biology, or a related field.
1+ year industrial drug development experience
1+ years of hands-on experience in an aspect of display campaigns or genomics approaches in protein design or directed evolution projects
Demonstrated proficiency in one or more of the following workstreams: library design and generation, display-based selection, and assay development
Strong molecular biology background and experience.
Cell culture experience (bacterial, mammalian, and/or yeast) is required
Excellent problem-solving skills, with the ability to troubleshoot technical issues and implement effective solutions
Outstanding organizational skills, attention to detail, and the ability to manage multiple projects simultaneously in a fast-paced environment
Strong communication and interpersonal skills, with the ability to collaborate effectively within multidisciplinary teams

Nice To Haves

Library generation experience is a plus
Experience in FACS-based selection and sorting preferred

Responsibilities

Design and generate display libraries with guidance from experimental and computational data. This includes library preparation and QC, NGS sequencing, and flow cytometry-based lead selection.
Culture engineered yeast for use in lead selection and sorting.
Construct/convert immune-based repertoires from immunized animal sources for use in both discovery and protein engineering campaigns.
Troubleshoot technical issues and implement solutions to optimize lead molecules, ensuring data quality and integrity throughout the discovery and optimization process.