This role is an advanced independent researcher that plans, coordinates and executes complex research projects. Works with the Principal Investigator. Participates in and assists in the planning and coordination of research projects, is independent and responsible for a specific aspect of the one or more research projects. Assists in determining the direction of the project. Prepares and writes manuscripts and research proposals, performs data management and quantitative analyses, collaborates in development of innovative research and educational programs, and serves as an educational resource for the laboratory and the Institution. A research associate scientist position is available in the Lefebvre laboratory at the Children’s Hospital of Philadelphia (CHOP) Abramson Research Institute. The fellow will contribute to a project aimed at elucidating mechanisms whereby SOX5 variants cause Lamb-Shaffer syndrome, a neurodevelopmental disorder characterized by global developmental delay, intellectual disability and autism spectrum disorder features and at testing a gene therapy candidate approach for this disorder in preclinical models. The fellow will use cutting-edge approaches in mouse genetic models, human iPSC-derived brain organoid models, high-throughput ‘omics’ approaches and gene therapy strategies. Successful accomplishment of this research is anticipated to deepen fundamental scientific knowledge and to increase mechanistic understanding of neurodevelopmental diseases and our ability to treat them. It is also anticipated to help the fellow launch a promising career as an independent research investigator.
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Job Type
Full-time
Career Level
Senior