Research Associate II/ Senior Research Associate

Generate Biomedicines•Andover, MA

3h•Onsite

About The Position

Generate Biomedicines is seeking a Research Associate II/Senior Research Associate to join our CryoEM Group in generating large-scale protein structural datasets. This role offers the opportunity to work at the intersection of protein biochemistry and cutting-edge structural biology, contributing to our mission of accelerating drug discovery through advanced imaging technologies.

Requirements

MSc in Biochemistry, Structural Biology, Biophysics, Molecular Biology, Chemistry, or a related field and 0-2+ years of experience, or a BSc in Biochemistry, Structural Biology, Biophysics, Molecular Biology, Chemistry, or a related field with 2-4+ years of related experience.
Hands-on experience in basic wet lab techniques, including pipetting, buffer preparation, and protein purification.
Strong understanding of protein chemistry concepts, such as molarity, protein concentration, and buffer formulation.
Ability to work in a fast-paced, collaborative research environment.
Strong attention to detail and ability to troubleshoot technical issues.

Nice To Haves

Familiarity with structural biology techniques and CryoEM sample preparation.
Prior exposure to CryoEM workflows or microscope operation with SerialEM.

Responsibilities

Perform protein purification, complexation, vitrification, and clipping, ensuring high-quality sample preparation for CryoEM.
Load and operate CryoEM microscopes, executing data collection with automated workflows.
Collaborate with multidisciplinary teams to support high-throughput protein structure determination.
Follow standard operating procedures (SOPs) and contribute to process optimization.
Document experimental data and report findings in internal databases.
Interpret and troubleshoot experimental data, contributing to planning and prioritization of concurrent CryoEM experiments.
Apply and refine data analysis methods; determine reliability of results and communicate findings in presentations or team meetings.
Contribute to process optimization and implementation of new protocols.