Research Associate I, CFPS Production

BigHat Biosciences • San Mateo, CA

7d • $75,000 - $88,000 • Onsite

About The Position

BigHat Biosciences is seeking a self-motivated individual for a Research Associate, CFPS Production role to manufacture, validate and execute experiments to develop cell-free protein synthesis (CFPS) reagents for BigHat’s high-throughput, automated platform for producing and characterizing antibodies.

Requirements

• B.S. degree in Biochemistry, Molecular Biology, or related field with 1-2 years of industry experience.
• Experience working with recombinant protein expression from bacterial cultures.
• Experience with molecular cloning techniques including primer design, PCR, mutagenesis, Golden Gate Assembly.
• Excellent communication skills; organized and works well in small groups.

Nice To Haves

• Experience with CFPS is highly desired but not required.
• Experience and knowledge of protein purification methods including affinity chromatography and SEC.
• Experience with quantitative and/or statistical analysis software is a plus (e.g. Excel, GraphPad Prism, Python, R, etc.)
• Experience with automation and high-throughput tools and robotic instrumentation is a plus.

Responsibilities

• Manufacture and validate CFPS reagents used in BigHat’s high-throughput antibody screening platform including making buffers, media for biomass production and performing QC experiments on reagents.
• Maintain CFPS reagent manufacturing equipment including incubators, centrifuges, and homogenizers.
• Coordinate with lab ops team to request/order supplies for CFPS reagent manufacturing to ensure reliable stock for platform.
• Design and run experiments for development of next generation CFPS extract to optimize yield and purity of next generation antibodies on our platform.
• Keep a detailed record of all experiments using BigHat’s documentation tools, and clearly communicate results and challenges.
• Present experimental plans and results during regular meetings with manager and science teams.

Benefits

• Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
• Dental, and vision coverage through Guardian
• Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
• 401(k) with company match
• DTO, two weeks of company-wide shutdown, and 12 company holidays
• Paid parental leave

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level