Research Associate 2, Histology
About The Position
As a Research Associate on the Histology team, you will be the foundation of platform development by maintaining and sectioning FFPE tissue blocks; support development of our proprietary tissue mounting system; use your background knowledge in histology and molecular diagnostics to identify controls, workflows, and enhancements to improve assay robustness and reliability; aid in expanding our assays to new tissue types, and provide guidance and expert advice to assay developers for interpreting results and expectations, and be the voice of histology when working with customers and collaborators. The ideal candidate will have a strong background in FFPE tissue sectioning and assessment using traditional histochemical staining such as H&E, familiarity in molecular assays on preserved tissue (e.g., IHC, IF, ISH/FISH) using a variety of microscopy readouts (brightfield, fluorescence etc.), and be comfortable following established complex assay workflows. You will be working with a multidisciplinary team of scientists in the fields of surface chemistry, engineering, biochemistry, and bioinformatics. This role is ideally suited to a candidate who is self-motivated and excited by a startup environment where opportunity to rise to frequent and diverse challenges is commonly encountered.
Requirements
- B.Sc. in Biochemistry/biomedical sciences or related field plus 2-3+ years of histology experience.
- 1-2 years of microtomy experience.
- Hands on experience in precision microtomy with a focus on minimizing tissue loss of precious samples.
- Experience with molecular pathology assays (e.g., immunohistochemistry, in situ hybridization, immunofluorescence) and performance in different tissue types.
- Experience with multiplexed assays is strongly preferred.
Nice To Haves
- Understanding of healthy and diseased clinical samples is a plus.
- Working knowledge of fluorescence microscopy is a plus.
Responsibilities
- Operate a microtome to produce consistent, high-quality FFPE tissue sections.
- Support development teams by providing expert advice and guidance on tissue handling, experimental design, expectations, and interpretation of results.
- QC FFPE tissues prior to using in assay development.
- Actively contribute to optimizing in situ workflows.
- Establish standards for onboarding and assessing performance of standard and new tissue types.
- Collaboration and effective communication with team members in (surface) chemistry, biochemistry, systems integration, image analysis, and bioinformatics.
- Maintain meticulous notes and databases of relevant reagents, experiments, equipment, and other processes.
- Contribute to writing SOPs and other documentation.
Benefits
- equity as part of the compensation package
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
