The Campbell lab studies the molecular mechanisms of autism spectrum disorder (ASD). The lab takes three distinct approaches, all of which use human cerebral organoids as a human model of early brain development. The first approach is to understand how genes with high confidence ASD mutations alter neurodevelopment. The second approach is to determine how common genetic variants with genome-wide significant association with ASD alter neurodevelopment. The third approach is to expose human cerebral organoids – with a variety of genetic backgrounds – to environmental factors that are associated with ASD risk. Collectively, these approaches will identify biochemical networks that can be targeted for therapeutics. The funded project involves extensive next generation sequencing (NGS) of RNA extracted from human cerebral organoids.
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Job Type
Full-time
Career Level
Mid Level