(Senior) RA, Peptide Chemistry

Nosis Bio • Alameda, CA

4d • Onsite

About The Position

Nosis Bio is a well-funded biotech startup exclusively focused on cell-specific delivery of RNA therapeutics. We are an all-scientist team of biologists, chemists, and machine learning experts that believe targeted extrahepatic delivery is the only thing preventing RNA therapies from becoming the standard-of-care for most chronic diseases. We combine deep expertise in receptor biology, generative AI, and high throughput in vivo data generation to exponentially accelerate the development of RNA therapeutics for new tissues. We are addressing a major unmet need across the industry and actively partner with pharmaceutical companies, research institutions, and biotech. We are seeking a RA / Sr. RA to conduct chemical synthesis and chromatographic purification of peptides, oligonucleotides and oligo-peptide conjugates to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) properties of therapeutic candidates. The successful candidate will have hands-on experience with peptide chemistry and will work closely with multidisciplinary teams to support various drug discovery projects.

Requirements

• Ability to work on site in our lab spaces located in the Research Park at Marina Village (Alameda, CA)
• Must have direct hands-on experience with solid phase peptide synthesis and downstream processing (cleavage, deprotection and purification)
• Motivated and proactive with strong problem-solving skills
• Ability to multitask and manage several projects simultaneously
• Team-oriented and open to collaboration across scientific disciplines

Nice To Haves

• Direct experience with automated peptide synthesizers (Liberty Prime and Multi Pep) highly preferred
• Previous experience with solid phase oligonucleotide synthesis and conjugation

Responsibilities

• Perform peptide synthesis on Liberty Prime and Multi-Pep synthesizer
• Perform conjugations of oligonucleotides and peptides to various chemical tags (biotin, fluorescent dyes, etc.)
• Perform HPLC purification and MS analysis of synthesized products
• Maintenance of chemistry instruments and supplies

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Associate degree