Director, Peptide Process Development
About The Position
The Director of Peptide & Peptide‑Oligonucleotide Conjugate (POC) Process Development will provide technical leadership for the development, scale‑up, and external manufacture of peptide and POC active pharmaceutical ingredients. This role is accountable for advancing robust, scalable, and regulatory‑ready processes from early development through clinical and commercial supply. This position requires a balance of hands‑on technical expertise, strong CDMO management experience, and cross‑functional leadership to deliver peptide and POC processes that are fit for development, manufacture, and future scale. This position is onsite and will be primarily located in Cambridge, MA.
Requirements
- PhD in a relevant scientific discipline with 10+ years of industry experience in peptide and/or conjugate process development.
- Demonstrated expertise in peptide API development, scale up, and process characterization.
- Experience in process development, optimization, scale-up, and process characterization of peptide-drug conjugates and/or oligonucleotide conjugates.
- Proven experience leading process transfer and external CDMO-based GMP manufacturing.
- Experience supporting CMC documentation and regulatory filings.
- Ability to function as a technical owner within cross-functional program teams.
Responsibilities
- Lead process development, optimization, scale up, and characterization of peptides and contribute to the development of peptide oligonucleotide conjugate (POC) APIs with internal stakeholders.
- Serve as the technical lead for peptide and POC processes from development through external GMP manufacture.
- Evaluate, select, and enable CDMOs; lead process transfer and external manufacturing activities.
- Author and review technical and regulatory documentation supporting API manufacture and filings.
- Integrate CMC process activities within TOQ and extended program teams.
- Contribute to long‑term peptide and POC platform strategy and delivery.
Benefits
- medical
- dental
- vision coverage
- life and disability insurance
- a lifestyle reimbursement program
- flexible spending and health savings accounts
- a 401(k)with a generous company match
- paid time off
- wellness days
- holidays
- two company-wide recharge breaks
- generous family resources and leave
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What This Job Offers
Job Type
Full-time
Career Level
Director
Education Level
Ph.D. or professional degree
