R&D Scientist, NGS

PREDICTA BIOSCIENCES INC•Somerville, NJ

2d•$95,000 - $125,000•Onsite

About The Position

Predicta is seeking a highly motivated, laboratory-based R&D Scientist to lead NGS assay development, including whole genome sequencing and single-cell RNA-seq. The scientist will develop assays for genomic characterization of tumor and immune cells, from low-input sample processing through NGS library preparation, sequencing, and quality control, translating early research concepts into clinical assays. The role works closely with laboratory-based scientists and computational biologists to improve blood-based cancer diagnostic capabilities. The position is based in Somerville, Massachusetts, near the Union Square T stop. It offers an annual salary range of $95,000–$125,000, with a 10% bonus opportunity. Predicta describes this as an opportunity to help advance precision diagnostics for hematologic cancers and shape the quality and performance of its clinical testing efforts.

Requirements

PhD in molecular biology, genomics, genetics, or a related field, or equivalent industry experience.
At least 5 years of hands-on laboratory experience in NGS assay development, preferably in a cutting-edge research or R&D environment.
Deep expertise in NGS technologies, including library preparation, sequencing platforms, and workflow optimization.
Hands-on experience optimizing NGS library preparation for low-input samples.
Experience evaluating sequencing-run and library QC metrics and troubleshooting NGS workflow performance.
Strong experimental design, troubleshooting, and data interpretation skills.
Demonstrated ability to work in cross-functional, fast-moving research or startup environments and collaborate with computational scientists.
Outstanding written and verbal communication skills.
Ability to handle several fast-paced projects concurrently.
Demonstrated curiosity and scientific rigor, with excellent problem-solving skills.

Nice To Haves

Experience with single-cell RNA-seq or related single-cell technologies, such as scWGS, scATAC-seq, or scMultiomics.
Experience with NGS applications in hematologic malignancies.
Experience developing and validating NGS assays under CLIA/CAP or other regulated quality systems.
Familiarity with computational methods and software for NGS data analysis, especially quality control.
Prior experience bringing assays from early research through product development.
Experience automating NGS library preparation and related sample processing.
Background in cancer genomics, hematologic malignancies, or immune-oncology.

Responsibilities

Design, develop, and optimize NGS assays for tumor cell and immune characterization.
Lead development and optimization of NGS workflows, including library preparation for whole genome sequencing and single-cell RNA-seq, such as 10x Genomics workflows.
Optimize library preparation for low-input and limited samples to improve sensitivity, yield, library complexity, and reproducibility.
Oversee sequencing on Illumina platforms, including run planning, pooling, and loading strategies.
Evaluate and implement technologies, reagents, and platforms to improve assay performance, robustness, and scalability.
Establish and maintain QC metrics, acceptance criteria, and assay validation practices across NGS workflows.
Collaborate with R&D and computational biology team members to integrate wet-lab and analytical workflows.
Develop and document SOPs, protocols, and technical reports suitable for regulated environments.
Maintain meticulous, reproducible records and contribute to shared protocols.
Follow, document, and adapt experimental protocols with care and precision.
Mentor junior scientists and contribute to best practices within the R&D organization.
Support technology transfer from R&D into product development and clinical operations as needed.