R&D Engineer II
About The Position
Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere. Our immune cell reprogramming team integrates foundational research on immunology and disease biology with AI-modeling to develop engineered cells that harness our own immune system to detect and treat early signs of age-related diseases, like cancer, Alzheimer’s, and Parkinson’s. These technologies will enable precise, context-dependent therapeutic responses only when and where it is needed. Our work brings together three powerhouse universities - Columbia University, The Rockefeller University, and Yale University - into a single collaborative technology and discovery engine. Our Vision Pursue large scientific challenges that cannot be pursued in conventional environments Enable individual investigators to pursue their riskiest and most innovative ideas Facilitate research by scientists and clinicians at our home institutions and beyond We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease. The Advanced Single Cell Technologies group provides critical single cell profiling and perturbation assays, technology, and expertise to the Biohub NY community. The goal of the platform is to develop cutting-edge single-cell technologies in collaborations related to studying human disease and the interaction of immune cells with human organs. The R&D Engineer II will create new technologies and devices for high throughput single-cell screening and will have demonstrated experience in designing, prototyping, testing and troubleshooting diagnostic or point-of-care medical devices. We are seeking a creative, methodical, resourceful, and technically rigorous engineer capable of driving projects independently and on a team. This role sits at the intersection of device engineering, cell biology/immunology, and reagent formulation, and requires an ability to own a problem end-to-end, from proof-of-concept demonstration to prototype and beyond. This role offers substantial design freedom with direct lab access for rapid testing.
Requirements
- Bachelor's or Master's Degree in Engineering (especially biomedical, chemical or mechanical engineering) plus 5+ years of relevant, post-graduate hands-on engineering experience. Holders of non-engineering degrees must have at least 6 years of hands-on engineering experience developing hardware.
- Track record of developing diagnostic or point-of-care medical devices
- Experience with handling biological samples
- Proficiency in CAD
- Experience with 3D printing and rapid prototyping
- Ability to independently design rigorous experiments, troubleshoot complex workflows, and drive projects to completion
- Strong documentation habits
- Collaborative mindset and strong scientific communication skills
Nice To Haves
- Wet lab experience (cell culture, basic molecular biology)
- Experience with reagent stabilization/lyophilization or dried-reagent formulation
- Knowledge of and proficiency in Python
- Experience with microfluidics and microfabrication
Responsibilities
- Design, build and test prototypes for point-of-care sample processing, iterating based on performance data and optimizing for reproducibility
- Design mechanisms for controlled timing and sequencing of biochemical processes within a device (e.g., controlled reagent release, passive valving, or equivalent)
- Perform hands-on preparation and handling of biological specimens, and conduct assay validation experiments (e.g., timing precision, reagent activity, sample/cell quality at endpoint)
- Apply domain knowledge across device engineering, cell biology, and materials science to guide hardware design decisions
- Establish test protocols and acceptance criteria to ensure reproducible performance across prototype iterations and production lots
- Participate in discussions with project collaborators
- Carefully document work
- Clearly report on project progress
- Contribute to scientific publications and patent applications
Benefits
- Generous employer match on employee 401(k) contributions
- Paid time off to volunteer at an organization of your choice
- Funding for select family-forming benefits
- Relocation support
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
