Associate Director/Director, Program Manager, CLYM116

Climb Bio•Newton, MA

1d•$195,000 - $255,000•Hybrid

About The Position

Climb Bio is seeking an Associate Director or Director Program Manager for its CLYM116 program. This cross-functional role translates the asset strategy into an integrated execution plan and drives day-to-day delivery. Reporting to the CLYM116 Program Leader, the Program Manager owns the integrated program timeline, risk management, and operating rhythm, helping ensure the team remains aligned, decisions are documented, and commitments are met. The role works closely with Clinical Development, Clinical Operations, Regulatory, CMC, Nonclinical, Quality, Finance, and Commercial, and supports the Program Leader in managing the development-partner collaboration. The Program Manager converts the Integrated Development Plan into a detailed program schedule, tracks commitments and status, leads forward planning and scenario analysis, and manages program risks, issues, and dependencies. The role prepares leadership updates and Board materials, supports governance and decision-making, integrates study and functional plans, and coordinates partner governance, actions, milestones, and deliverables. The successful candidate will also use AI tools, automation, and integrated systems to improve planning, reporting, and communication, and may support broader portfolio and process-improvement initiatives. This is a hybrid position based at Climb Bio’s Wellesley, Massachusetts office. The listed base salary range is $195,000–$215,000 for Associate Director and $220,000–$255,000 for Director. Additional total rewards include a discretionary annual bonus, comprehensive benefits, paid time off, and equity.

Requirements

At least 8 years of biotechnology or pharmaceutical drug-development experience; 10 or more years for Director.
At least 5 years of program or project management on clinical-stage programs; 7 or more years for Director.
Drug-development experience from pre-IND through Phase 2, including management of integrated cross-functional plans across clinical, regulatory, CMC, and nonclinical workstreams.
Ability to facilitate a cross-functional matrix team, reach decisions, and drive delivery without direct reporting authority.
Working knowledge of program budgets and experience partnering with Finance on spend tracking and planning inputs.
Hands-on fluency with AI tools and willingness to learn, adopt, and build AI-enabled ways of working for program planning, tracking, and communication.
Excellent written and verbal communication skills, including preparation of materials for executive audiences.
Bachelor’s degree in life sciences, business, or a related field.

Nice To Haves

Phase 3 experience.
Advanced degree (MS, PhD, PharmD, MBA, or equivalent) or PMP certification.
Experience supporting a program through Phase 3 start-up, registration, or launch readiness.
Strong working knowledge of the drug-development lifecycle, including IND/CTA submissions, global health authority interactions, major regulatory submissions, and transition from early clinical to registrational studies.
Experience supporting a co-development, licensing, or collaboration partnership.
Experience building and scaling AI-enabled workflows, such as AI assistants, automation, and live dashboards, to improve planning, reporting, and decision-making.
Experience with low-code automation, APIs and data integration, or BI platforms such as Power Automate, Smartsheet integrations, or Power BI.
Experience in a lean, clinical-stage organization where program teams work hands-on across functions.

Responsibilities

Translate the CLYM116 Integrated Development Plan into and own an integrated program timeline, including detailed schedules, interdependencies, critical path, and resourcing; lead day-to-day execution with the Program Leader.
Maintain a shared, current view of program commitments and status, from regulatory interactions and clinical studies through registrational development and launch readiness.
Prepare regular program updates for leadership and develop materials for Board presentations, communicating program status, risks, and decisions clearly and concisely.
Lead forward planning and scenario analysis covering timelines, enrollment, study design, and investment options to inform decisions.
Manage program-level risks, issues, and dependencies; drive mitigation and contingency plans and escalate appropriately.
Run the program team operating rhythm, including agendas, pre-reads, decision and action logs, minutes, and follow-through.
Partner with the Program Leader to implement governance processes, decision frameworks, and accountability mechanisms, and prepare clear asks, options, and recommendations for governance forums.
Integrate study-level plans and status from Clinical Operations, including the Clinical Program Lead, and align workstream plans and dependencies with CMC, Regulatory, and Nonclinical.
Support partner collaboration by coordinating joint governance, tracking actions, contract milestones, and deliverables, and surfacing issues early.
Partner with the Program Leader, functional leaders, and Finance on annual and long-range planning inputs, and flag contract and SOW changes that affect the plan.
Use AI tools, automation, and integrated systems such as Smartsheet, Microsoft 365, and AI assistants to streamline planning, reporting, and communication; build reusable templates, dashboards, and workflows.
Lead or support cross-functional initiatives beyond CLYM116 as priorities evolve, including portfolio planning, process improvement, and shared program management tools.