Process Development Scientist - Torrance
About The Position
PolyPeptide is seeking a Process Development Scientist to support the design, execution, optimization, and scale-up of synthetic processes for peptide and/or oligonucleotide API development. This role is a strong fit for a scientist who enjoys hands-on process development, technical problem-solving, and working closely with cross-functional teams to move projects from development into scalable, cGMP-compliant manufacturing. As a Process Development Scientist, you will play an important role in developing robust, efficient, and cost-effective processes that support clinical and commercial manufacturing. Your work will directly contribute to PolyPeptide’s commitment to quality, technical excellence, and on-time delivery for our customers. The transition from laboratory development to manufacturing is a critical step in delivering high-quality APIs to customers. In this role, you will help bridge that gap by applying your expertise in organic chemistry, peptide chemistry, purification, process development, and technology transfer. You will have the opportunity to contribute to meaningful projects, solve complex technical challenges, and support processes that are essential to pharmaceutical development and manufacturing.
Requirements
- Ph.D. in Chemistry, Chemical Engineering, or a related discipline with at least 1 year of relevant experience, or Master’s degree with at least 5 years of relevant experience
- Industry experience with a focus on organic chemistry
- Strong knowledge of synthetic organic chemistry, process development, and analytical techniques
- Ability to interpret analytical results and apply sound scientific judgment
- Strong analytical thinking and problem-solving skills
- Ability to work independently while also collaborating with multidisciplinary teams
- Strong communication skills and attention to detail
Nice To Haves
- Experience with peptide chemistry and downstream purification preferred
- Experience with peptide chemistry, oligonucleotide chemistry, or API development
- Experience with HPLC purification, analytical HPLC, lyophilization, and drying processes
- Experience with scale-up and technology transfer into manufacturing environments
- Familiarity with cGMP requirements and regulatory expectations for clinical or commercial manufacturing
- Experience working in a CDMO, pharmaceutical, biotech, or regulated manufacturing environment
Responsibilities
- Plan and coordinate technology transfer activities from Development to Production, both onsite and across sites
- Design, execute, and optimize synthetic processes for peptide and/or oligonucleotide API development
- Perform intermediate chemical processing steps using established safety and process procedures
- Check reactor systems for proper operation in accordance with SOPs and operating manuals
- Monitor chemical reactions during processing and respond appropriately to ensure proper execution
- Prepare solutions for purification
- Interpret test results and take appropriate action to support acceptable processing
- Purify crude peptide using HPLC under minimal supervision
- Conduct lyophilization and drying processes according to established procedures
- Perform in-process checks of fractions using analytical HPLC and report results to supervision or senior development personnel
- Support troubleshooting of equipment and processing issues
- Identify and report deviations, equipment concerns, or unresolved processing issues
- Maintain high standards for safety, housekeeping, and cleanliness
- Support cross-functional project teams with technical expertise
- Perform additional duties aligned with the needs of the role and organization
Benefits
- Equal opportunity employer
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
