Principal Software Engineer

eClinical Solutions•Mansfield, MA

About The Position

eClinical Solutions is transforming clinical development with elluminate®, our Clinical Data Cloud, helping life sciences organizations unify, analyze, and unlock the value of their data faster than ever before. By combining a modern cloud platform with expert data services, we empower smarter decisions across the clinical trial lifecycle—accelerating innovation that ultimately improves patient outcomes. Our engineering teams build enterprise-grade, revenue-generating products at the intersection of cloud, data, analytics, and emerging AI technologies. If you’re excited about building sophisticated software that makes a real-world impact on healthcare, this is the place to do it. You will make an impact: As a Principal Full Stack Software Engineer, you will be a technical leader within the elluminate Product Development team. You’ll help design and build the core services and user experiences of a next-generation clinical data and analytics platform—while influencing architecture, engineering standards, and technical direction. This role is ideal for an experienced engineer who enjoys hands-on development, mentoring others, and bringing modern capabilities—including AI-assisted and agentic workflows—into production-grade systems. AI & Modern Engineering Focus We’re actively incorporating AI-powered capabilities into our platform, and you’ll help shape how this is done responsibly and effectively in an enterprise environment. This includes: Integrating LLMs and AI services into .NET- and Python-based systems Designing and implementing AI-assisted workflows, copilots, or intelligent automation features Working with agentic AI patterns (e.g., task orchestration, tool-using agents, workflow automation) Applying prompt engineering, evaluation techniques, and guardrails to ensure reliability and compliance Collaborating with data and platform teams to operationalize AI—not just prototype it Deep ML expertise is not required—we’re looking for strong engineers who understand how to apply AI capabilities in real products. Take the first step toward your dream career. Here is what we are looking for in this role.

Requirements

Bachelor’s or Master’s degree in Computer Science or equivalent practical experience
10+ years in software design and development using the Microsoft technology stack preferred
Expert-level proficiency in C#, .NET, and ASP.NET (MVC/Web APIs)
Strong experience building full-stack web applications (Angular, TypeScript, HTML, CSS)
Solid understanding of software design principles, patterns, and best practices
Experience across the full Software Development Lifecycle (Agile preferred)
Proven ability to work independently while collaborating effectively in a fast-paced environment
Excellent communication, documentation, and technical leadership skills
Hands-on experience integrating LLM-based services (e.g., OpenAI, Azure OpenAI, or similar) into applications
Experience using Python and/or .NET alongside AI/LLM workflows
Familiarity with agent-based or workflow-driven AI architectures is a strong plus
Understanding of secure and responsible AI usage in enterprise systems

Nice To Haves

Strong SQL expertise (Microsoft SQL Server preferred), including performance tuning
Experience with microservices, distributed systems, and cloud platforms (AWS preferred)
Secure development experience, including awareness of common vulnerabilities and mitigations
Experience with clinical trial data, life sciences, or regulated SaaS environments
Experience building data visualizations or analytics-driven user experiences

Responsibilities

Design, develop, test, and deploy scalable, secure, and highly interactive web applications
Own and evolve core platform modules, from concept through release and support
Influence application and system architecture with a focus on performance, reliability, security, and maintainability
Lead by example through clean, well-tested code, thoughtful design reviews, and pragmatic technical decisions
Collaborate closely with Product Management, QA, and other engineers throughout the SDLC
Provide technical mentorship and guidance to other engineers on the team
Diagnoses and resolves complex production issues across distributed systems
Ensure solutions meet eClinical Solutions quality standards and applicable industry regulations
Contribute to technical documentation including design specs, acceptance criteria, and release notes

Stand Out From the Crowd

Upload your resume and get instant feedback on how well it matches this job.

Upload and Match Resume