Principal Scientist – Oligonucleotide & AOC Analytical Chemistry
About The Position
Atrium Therapeutics is seeking an experienced analytical scientist at the Principal Scientist level to build and lead analytical characterization of antibody-oligonucleotide conjugates (AOCs) designed to deliver siRNA payloads selectively to cardiomyocytes. The scientist will develop phase-appropriate analytical methods for AOC drug substance, drug product, and intermediates, including antibody, siRNA duplex, and linker-oligonucleotide. The role will generate data that informs conjugation chemistry, process development, stability, and specifications for IND-enabling and early clinical programs. The role is primarily lab-based and will help establish analytical capabilities within Chemistry & Technical Development. The scientist will partner with Biology, Developmental Sciences, external CDMOs, and contract testing laboratories.
Requirements
- Ph.D. in analytical chemistry, biochemistry, chemistry, or a related field with 8+ years of relevant industry experience; or M.S. with 12+ years; or B.S. with 14+ years.
- Demonstrated analytical leadership on AOC, ADC, or oligonucleotide conjugate programs through IND or later.
- Expert hands-on experience with HPLC/UHPLC (SEC, HIC, IEX, IP-RP) and LC-MS of proteins and/or oligonucleotides, including data processing and deconvolution.
- Experience with capillary electrophoresis (CE-SDS, icIEF) and spectroscopic quantitation.
- Experience with method transfers and impurity characterization through all development phases.
- Strong problem-solving skills, attention to detail, and clear written and oral communication in a fast-paced, cross-disciplinary team.
- Ability to manage multiple projects independently, prioritize competing deliverables, and meet timelines in a fast-paced, cross-functional environment.
Nice To Haves
- Familiarity with antibody chemistries and their analytical signatures.
- Experience with SEC-MALS, native MS, peptide mapping, or hybridization-based and ligand-binding assays.
- Publication or patent record in bioconjugate or oligonucleotide analytics.
- Experience with statistical software such as JMP or Design-Expert for data analysis.
Responsibilities
- Lead efforts to build internal analytical capabilities and laboratory infrastructure.
- Develop, optimize, qualify, and transfer analytical methods for AOCs, oligonucleotide intermediates, and related materials.
- Design and execute forced-degradation and development stability studies, and elucidate degradation pathways for antibody and oligonucleotide components.
- Serve as analytical lead and provide in-process and release-type analytical testing of oligonucleotides and conjugates in support of discovery, process development, and GLP studies.
- Partner with oligonucleotide and AOC bioconjugation teams to develop analytical methods for characterizing and quantifying process intermediates and impurities.
- Evaluate and implement new analytical technologies to strengthen oligonucleotide and AOC characterization.
- Maintain rigorous electronic lab notebook records and present data and recommendations to project teams.
- Author and review method SOPs, technical reports, and analytical sections supporting GLP studies and regulatory submissions.
Benefits
- Stock options and RSUs.
- 401(k) with employer match.
- Wellness program including medical, dental, vision, and LTD coverage.
- Unlimited time off, including summer and winter breaks.
- Learning and development programming, job-specific industry training opportunities, and education reimbursement.
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What This Job Offers
Job Type
Full-time
Career Level
Principal
Education Level
Ph.D. or professional degree
