Scientific & Translational Biomarker

UCB • San Diego, CA

3d • $138,000 - $181,000 • Hybrid

About The Position

UCB is seeking a scientifically rigorous, collaborative, and results-focused Principal Scientist to join its Translational Medicine and Biomarkers team. The role leads translational biomarker projects connecting drug discovery programs with clinical development, evaluates mechanisms of action and pharmacokinetic and pharmacodynamic relationships, shapes biomarker strategy in autoimmune disease, and translates complex data into clear program decisions. The position may be based in the Candid offices in San Diego, California, or performed remotely within the United States, and reports to the Executive Director, Translational Medicine.

The Principal Scientist works in a multidisciplinary environment with Discovery, Clinical Development, Clinical Pharmacology, and Clinical Operations colleagues. The role also partners with contract research organizations, external collaborators, and scientific stakeholders to develop assays, oversee study samples, interpret results, and communicate findings.

UCB describes itself as a global biopharmaceutical company focused on neurology and immunology, with more than 9,000 employees. Its culture emphasizes collaboration, innovation, inclusion, employee growth, and creating value for patients. UCB has embraced a hybrid-first approach, with roles generally hybrid and 40% office time unless the description or nature of the position specifies otherwise.

Requirements

• Doctorate in immunology, rheumatology, molecular biology, or a related field.
• At least 4 years of biotechnology or pharmaceutical biomarker-development experience.
• Proven knowledge of autoimmune disease biology and translational molecular technologies.
• Validated experience developing qualified flow cytometry panels with external research partners.
• Demonstrated project leadership, organization, and milestone-tracking skills.
• Fluency in written and spoken English.
• Willingness to travel up to 10%.

Nice To Haves

• Experience with T-cell engagers or bispecific antibody therapeutics.
• Experience with preclinical biomarkers and disease models.
• Experience with single-cell RNA sequencing or immune-repertoire sequencing.
• Proficiency in data analysis and visualization using R, Python, or similar tools.
• Ability to thrive independently in a fast-paced, entrepreneurial environment.

Responsibilities

• Lead biomarker projects supporting preclinical and clinical program decisions.
• Develop translational hypotheses for treatment response and non-response.
• Shape translational research strategy for autoimmune disease programs.
• Interpret and present biomarker data to internal and external stakeholders.
• Guide assay development and study-sample oversight with external research partners.
• Support translational content for clinical and regulatory documents.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Education Level: Ph.D. or professional degree