Principal Scientist - Cell Therapy Translational Research

Bristol Myers Squibb • Seattle, WA

3d • $152,360 - $184,628 • Onsite

About The Position

The Principal Scientist will join Bristol Myers Squibb’s Cellular Therapy Translational Research group in Seattle, Washington, supporting cell therapy development programs for autoimmune and inflammatory diseases. The role is responsible for driving and implementing translational development strategies and clinical biomarker plans for cellular therapy clinical studies. The scientist will work with contract research organizations and internal and external collaborators to design, execute, and interpret translational experiments and analyses. This work includes identifying biomarkers and generating and analyzing data for pharmacodynamic evaluation and mechanism-of-action assessment in clinical trials, informing cell therapy product development, and contributing to global regulatory submissions.

The role involves leading translational research strategies, developing product mechanism-of-action hypotheses, managing internal drug-development projects, and serving as the scientific functional lead on cross-functional teams. The Principal Scientist also oversees CROs and academic collaborators, communicates findings to internal and external audiences, and contributes to regulatory documents and responses. The position is part of BMS’s Cell Therapy Thematic Research Center, which develops engineered cell-based therapies intended to harness the immune system to improve outcomes in hematologic malignancies, solid cancers, and autoimmune disease.

Requirements

• Bachelor’s degree and 8 or more years of academic and/or industry experience; or master’s degree and 6 or more years; or Ph.D. or equivalent advanced degree in the life sciences and 4 or more years.
• Expertise in immunology or cellular biology.
• Expertise in developing and analyzing biomarkers for clinical trials.
• Experience analyzing high-content datasets, such as transcriptomic or proteomic data.
• Excellent communication and interpersonal skills, including the ability to interact with and influence research scientists, project teams, external collaborators, and commercial vendors.
• Detail-oriented, with the ability to identify and implement creative solutions.
• Ability to prioritize and manage time efficiently.

Nice To Haves

• M.S. or Ph.D. in immunology, molecular and cellular biology, or a relevant discipline.
• M.S. with 10 or more years of experience or Ph.D. with 5 or more years of experience, preferably in biotechnology or pharmaceuticals, or demonstrated deep experience in immunology or cell therapy academic research.
• Knowledge of the fundamentals of autoimmune and inflammatory diseases.
• Familiarity with the drug-development process from IND filing to market authorization in an industry setting.

Responsibilities

• Develop and implement end-to-end translational research strategies for cell therapy clinical trials.
• Partner with biostatisticians and computational biologists to analyze and communicate data promptly, explaining its context and impact.
• Develop concepts and mechanism-of-action hypotheses that identify distinguishing characteristics of BMS cell therapy products, alone or in combination with other therapies.
• Maintain a deep understanding of biomarker assays, including flow cytometry, transcriptomics, and proteomics, and their use in clinical trials.
• Independently manage internal cell therapy drug-development projects.
• Serve as scientific functional lead on internal cross-functional project teams and committees.
• Oversee and manage contract research organizations and academic collaborators.
• Communicate regularly and prepare and deliver presentations to the department, external audiences, and internal governance committees as required.
• Contribute to investigator brochures, IND applications, clinical protocols, regulatory annual reports, and other regulatory documents as appropriate.
• Support regulatory submissions and interactions, including writing or reviewing translational sections for global regulatory responses and queries.

Benefits

• Comprehensive benefit plans, including wellbeing support, retirement and financial protection benefits, and medical, dental, vision, life, and disability insurance offerings, subject to plan terms and eligibility.
• U.S.-based exempt employees are eligible for Flexible Time Off without a set accrual limit, subject to manager approval, and 11 paid company holidays annually.
• Depending on eligibility, additional time-off benefits may include paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs.
• Eligible employees may receive an annual Global Shutdown between Christmas Day and New Year’s Day.
• Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires, subject to manager approval, 11 paid company holidays, and 3 optional holidays.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal