Principal Scientist

Sanofi•Waltham, MA

18h•$122,250 - $176,583•Hybrid

About The Position

The Genomic Medicine Unit (GMU) CMC group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant AAV vectors, lentiviral vectors and cell therapy products. Sanofi is looking for an experienced cell culture development professional with experience in cell therapy process development to join the Genomic Medicine Cell Therapy Process Development Group located in Waltham, MA in the role of Senior Scientist. The Genomic Medicine Cell Therapy Development group within Sanofi operates with the mission to develop robust, scalable, and innovative cell culture processes for Sanofi’s genomic medicine pipeline. This position is a senior individual contributor embedded within the Upstream Scale-Up Laboratory, responsible for execution of cell culture bioprocesses at pilot and manufacturing scales (200L–2000L). This role serves as a technical cornerstone of the scale-up team, driving process understanding, operational excellence, and cross-functional alignment with downstream Scale-Up Laboratory team and manufacturing organizations. While this position carries no direct people management responsibilities, the incumbent is expected to demonstrate strong technical leadership — guiding peers, influencing process strategy, and serving as a subject matter expert (SME) in upstream bioprocessing. The role operates at the intersection of process science, engineering rigor, and operational execution, requiring both hands-on laboratory proficiency and the strategic mindset to translate bench-scale learnings into robust, scalable processes. Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

Requirements

Master’s degree in Chemical Engineering, or related discipline with a minimum of 6 years of relevant experience to large-scale bioreactors, or a Ph.D degree with a minimum of 4 years of industry experience related to large-scale bioreactors.
Strong background in cell culture bioreactor operations and scale-up technologies.
Experience in the biotech/pharmaceutical industry within a cell culture role and an excellent understanding of the operational excellence.
Experience with perfusion process operations at various scales.
Understanding of engineering principles related to cell culture process is required.
Ability to lead matrix teams for operations and lab management.

Nice To Haves

Experience managing cross-functional team and initiatives.
Experience in cell culture process development for AAV manufacturing.
Expertise in mammalian cell culture and related aspects such as cell metabolism/media optimization, engineering fundamentals on cell culture scale-up/down, cell biology/physiology.
Process automation experience.

Responsibilities

Lead scale-up activities from bench scale to pilot scale (200L–2000L), applying engineering principles (mixing, mass transfer, shear stress, dissolved oxygen control) to ensure process comparability at large scale.
Collaborate with process development scientists to translate laboratory findings into scalable, robust manufacturing processes.
Review and approve JSAs written by equipment owners and provide feedback.
Train employees to adopt best practice for safety, efficiency and operational success.
Build robust internal interfaces with the CMC community and promote the adoption of best practices.
Demonstrate expertise in upstream process operations at all scales.
Lead root cause analysis (RCA) investigations for process deviations, equipment failures at pilot scale.
Present findings and/or results to senior management, external stakeholders, and industry leaders at national/international conferences.