Principal Scientist - RGM Chemistry

Regeneron Pharmaceuticals • Hawthorne, CA

4d • $128,600 - $210,000 • Onsite

About The Position

We are looking for a visionary Principal Scientist – RGM Chemistry to lead the discovery, development, and optimization of antibody-oligonucleotide conjugation technologies that power next-generation targeted therapeutics. Sitting at the intersection of bioconjugation chemistry, RNA science, and process innovation, you will set scientific strategy, guide a multidisciplinary team, and translate ground breaking concepts into scalable solutions that advance our therapeutic pipeline. Your deep expertise, collaborative attitude, and passion for mentoring will drive breakthrough medicines from bench to preclinical validation and beyond.

Requirements

• A Ph. D. in Chemistry, Biochemistry, Molecular Biology, or related field with 5+ years of postdoctoral or industry experience in antibody/oligonucleotide conjugation
• Validated expertise in bioconjugation, oligonucleotide therapeutics, and advanced analytical techniques (HPLC, LC-MS, bioassays)
• Proven leadership of multidisciplinary teams and successful track record in advancing therapeutic candidates toward preclinical or clinical development

Nice To Haves

• Thrive on pushing the boundaries of antibody and oligonucleotide conjugation science
• Enjoy mentoring and developing talent in a collaborative, fast-paced research environment
• Translate sophisticated data into clear, actionable insights and strategic plans
• Demonstrate a strong record of innovation, publications, and/or patents in bioconjugation or RNA therapeutics
• Excel at balancing deep scientific rigor with pragmatic process development and scale-up considerations
• Are motivated by cross-functional collaboration that accelerates breakthrough medicines to the clinic

Responsibilities

• Designing and completing experiments to refine linker chemistry, payload stability, and delivery efficiency for antibody-oligo conjugates
• Analyzing conjugates with HPLC, LC-MS, and bioassays to ensure purity, identity, and functional potency
• Leading project stand-ups, mentoring scientists and research associates, and troubleshooting technical challenges in real time
• Partnering with Process Development and Manufacturing to scale promising conjugation methods for preclinical supply
• Scouting and evaluating emerging bioconjugation or RNA delivery technologies, then proposing data-driven innovation projects
• Presenting program updates and strategic recommendations to senior R&D leadership and cross-functional partners

Benefits

• health and wellness programs (including medical, dental, vision, life, and disability insurance)
• fitness centers
• 401(k) company match
• family support benefits
• equity awards
• annual bonuses
• paid time off
• paid leaves (e.g., military and parental leave)

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Education Level: Ph.D. or professional degree