Principal Scientist- NMR Spectroscopy

Pace® Analytical Services•Morrisville, NC

51d•$110,000 - $120,000•Onsite

About The Position

This is a full-time, onsite, Principal Scientist – NMR Spectroscopy position located in Research Triangle Park (RTP) Morrisville, NC, Monday through Friday, 8:00 a.m. - 4:30 p.m. The Principal Scientist – NMR Spectroscopy is a senior technical leader responsible for biomolecular and small‑molecule NMR characterization within a fast‑paced CRO environment. This role provides expert‑level guidance in NMR spectroscopy and complementary analytical techniques to support structure confirmation, reference standard qualification activities, method development, and GMP/GLP‑aligned laboratory operations. The Principal Scientist serves as the technical authority for NMR instrumentation and data interpretation, leads complex investigations, supports client engagement and cross‑functional initiatives, and mentors scientists through innovation, scientific rigor, and collaboration.

Requirements

Ph.D. in Chemistry, Analytical Chemistry, Physical Chemistry, or a related scientific discipline preferred; candidates with a master’s or bachelor’s degree and extensive NMR experience may also be considered.
Minimum of 8–10 years of analytical chemistry experience in a CRO, pharmaceutical, or regulated laboratory environment.
Expert‑level proficiency in NMR spectroscopy is required, including structural elucidation, advanced method development, and biomolecular NMR experience with proteins and oligonucleotides.
Demonstrated experience leading scientific teams, mentoring staff, or providing technical leadership.
Experience in GMP/GLP laboratory environments strongly preferred.
Deep understanding of NMR theory, pulse sequences, spectral interpretation, and instrument operation.
Strong knowledge of biomolecular NMR principles and their application to proteins and oligonucleotides.
Strong working knowledge of compendial requirements (USP/EP/JP) and analytical quality systems.
Working knowledge of chromatography, mass spectrometry, and other characterization techniques to support orthogonal testing.
Understanding of laboratory quality systems, data integrity principles, and regulatory expectations.
Experience with NMR data processing software (e.g., TopSpin, MNova, VnmrJ, Mdrive).
Expert‑level ability to interpret complex NMR spectra and integrate data across multiple analytical platforms.
Demonstrated ability to apply biomolecular NMR approaches to the characterization of proteins and oligonucleotides.
Strong leadership, mentoring, and team‑building capabilities.
Ability to manage multiple high‑priority projects in a client‑driven environment.
Excellent technical writing, documentation, and communication skills.
Strong problem‑solving, critical thinking, and scientific decision‑making abilities.
Ability to present complex scientific information to clients, auditors, and internal leadership.

Responsibilities

Leads biomolecular NMR characterization of protein and oligonucleotide samples, including sample handling and preparation, assessment of suitability and stability, execution of multidimensional NMR experiments, and application of testing requirements and orthogonal characterization workflows to support structure confirmation, method development, and data interpretation.
Leads small‑molecule NMR analysis, including 1D and 2D experiments (¹H, ¹³C, COSY, HSQC, HMBC, NOESY, etc.), to support identity, purity, and structural confirmation of chemical entities.
Demonstrates knowledge of reference standard qualification requirements, including analytical study design and the use of NMR and orthogonal techniques such as mass spectrometry, HPLC, FTIR, UV‑Vis, TGA, DSC, and Karl Fischer.
Serves as the primary technical authority for NMR instrumentation, including method development, optimization, troubleshooting, calibration, and maintenance oversight.
Supports marketing strategy, service positioning, and client engagement by contributing technical insight and participating in client discussions to align analytical solutions with project objectives.
Partners with clients to address technical questions, propose analytical strategies, and support project planning and timelines.
Represents the analytical team in client meetings, audits, and internal leadership discussions, and communicates complex scientific concepts clearly and effectively.
Guides method transfers, validations, and cross‑functional scientific initiatives and contributes to resource planning and project prioritization.
Interprets and reviews complex analytical data, reports, and COAs to ensure scientific rigor, compliance, and regulatory readiness.
Leads technical investigations, OOS/OOT assessments, and CAPAs and reinforces compliance with GMP/GLP, compendial requirements, internal SOPs, and best practices in safety, documentation, and data integrity.
Contributes to a collaborative, high‑performance culture through leadership, professionalism, and scientific excellence.
Identifies and implements process improvements, new technologies, and workflow enhancements to strengthen laboratory capability and efficiency.
Mentors and develops junior and mid‑level scientists and provides structured training in NMR theory, operation, and data interpretation.