Principal Scientist, Medicinal Chemistry

C4 Therapeutics Inc • Watertown, MA

1d

About The Position

C4 Therapeutics (C4T) is a clinical-stage biopharmaceutical company focused on developing targeted protein degradation science to create new medicines. The company is advancing targeted oncology programs and using its TORPEDO® platform to design and optimize small-molecule medicines for difficult-to-treat diseases. C4T's degrader medicines aim to utilize the body's natural protein recycling system to degrade disease-causing proteins, potentially overcoming drug resistance and improving patient outcomes.

Requirements

• PhD in organic and/or medicinal chemistry.
• Minimum of eight years of relevant biopharmaceutical or pharmaceutical experience in medicinal chemistry roles.
• Experience solving challenging problems in drug discovery through medicinal chemistry optimization.
• Demonstrated expertise in synthetic organic chemistry, including methodologies, transformations, and mechanisms.
• Proven scientific track record of advancing small molecules through stage gate milestones, from Hit ID through candidate selection, including optimizing degraders, including ligand optimization in the presence (and/or absence) of structural data.
• Experience managing CRO chemistry efforts to ensure appropriate use of resources and timely delivery of compounds.
• Experience closely working with Drug Metabolism and Pharmacokinetic (DMPK) colleagues on the in vitro and in vivo optimization of DMPK parameters to progress compounds.

Nice To Haves

• Experience in working across multiple drug modalities, including ADC / DACs.
• Hands-on experience utilizing and implementing computational tools (Maestro, MOE, or similar) to the design of compounds and integration of computational data into a continual design-synthesize-test-data analysis cycle.

Responsibilities

• Provide medicinal chemistry leadership on small molecule heterobivalent and monovalent (glue) degrader projects.
• Enable expeditious advancement of Structure Activity Relationships (SAR) through creative contributions to medicinal chemistry design, including effective collaboration with Biological Sciences, Computational Chemistry and Structural Biology colleagues.
• Independently lead medicinal chemistry efforts on heterobivalent and/or monovalent degrader projects.
• Manage external chemistry efforts at CROs (Contract Research Organizations).
• Critically analyze data and communicate findings effectively to multidisciplinary team members and leadership.
• Communicate clear, focused, and transparent updates to project teams, internal departments, and senior leadership.
• Make broad scientific contributions that have a positive impact on the research direction of the company.
• Contribute to and/or author patents, scientific presentations, and publications.

Benefits

• The base pay range for this position at commencement of employment is expected to be between $181,012.05 and $200,066.00 annually; however, base pay offered may vary depending on multiple individualized factors, including job-related knowledge, skills, and experience.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree