Principal Scientist, Mechanistic & Cellular Pharmacology

Johnson & Johnson•Spring House, PA

1d•Onsite

About The Position

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. We are searching for a talented scientist with an immunology background, deep expertise in disease biology and cellular pharmacology, and a passion for finding innovative therapeutics to treat diseases with high unmet medical need. You will be responsible for: Leading the development of innovative cell-based assays for immunology-focused projects to identify and evaluate targets, and to progress hits and lead molecules. Acting as a key liaison within the Mechanistic & Cellular Pharmacology team, across our broader Discovery Technologies & Molecular Pharmacology department, and with program teams, to enable project strategy and execution in partnership with cross-functional colleagues. Contributing to the integration of translational and mechanistic biology with novel AI/ML methods to enable the discovery of novel therapeutics. Collaborating closely with a multidisciplinary team of scientists to drive portfolio and platform initiatives. Analyzing and presenting data at program team meetings, in-house seminars, leadership meetings and external scientific conferences, and publish research in high-quality journals.

Requirements

A PhD in Immunology, Cell Biology or a related field is required.
A minimum of 4 years in a pharmaceutical industry setting, developing and applying novel cellular assays is required.
Proven track record in leading immunology-focused drug discovery programs across diverse modalities is required.
Expertise and proven accomplishments in de novo immunology cellular pharmacology assay development, complex immune cellular models and high-throughput technology platforms is required.
Experience with generating and culturing translationally relevant cell models such as iPSC-derived cells, primary cells, and/or co-cultures is required.
Expertise collecting and analyzing data using high dimensional approaches such as high content imaging and/or flow cytometry is required.
Strong experience as a problem solver and team collaborator able to facilitate understanding between biologists, chemists, and data scientists is required.
Demonstrated ability to apply novel approaches to address complex biology questions, as evidenced through strong peer-reviewed publications is required.
Excellent written communication, verbal communication, and oral presentation skills are required.

Nice To Haves

Expertise in assay automation and analysis workflows is preferred.
Expertise developing assays in translational and advanced cellular systems such as 3D models is preferred.
Exposure to neuroscience and/or oncology therapeutic areas is preferred.
Experience working with and/or guiding external collaborators in industry or academia is preferred.

Responsibilities

Leading the development of innovative cell-based assays for immunology-focused projects to identify and evaluate targets, and to progress hits and lead molecules.
Acting as a key liaison within the Mechanistic & Cellular Pharmacology team, across our broader Discovery Technologies & Molecular Pharmacology department, and with program teams, to enable project strategy and execution in partnership with cross-functional colleagues.
Contributing to the integration of translational and mechanistic biology with novel AI/ML methods to enable the discovery of novel therapeutics.
Collaborating closely with a multidisciplinary team of scientists to drive portfolio and platform initiatives.
Analyzing and presenting data at program team meetings, in-house seminars, leadership meetings and external scientific conferences, and publish research in high-quality journals.