Principal Scientist, Lentivirus Downstream Process Development

Legend Biotech US•Somerset, NJ

3h•Hybrid

About The Position

Legend Biotech is seeking a Principal Scientist, Lentivirus Downstream Process Development as part of the Technical Development team based in Somerset, NJ. The Principal Scientist, Lentivirus Downstream Process Development, will be a key technical leader responsible for designing, optimizing, and scaling purification processes for lentiviral vectors (LVV) within our innovative pipeline. This role focuses on delivering high-quality vector products to support LVV generation and other advanced cell therapy programs. The successful candidate will drive scientific excellence in downstream processing (DSP)—including clarification, chromatography, TFF, sterile filtration and fill/finish—ensuring processes are robust, scalable, and phase-appropriate for GMP manufacturing. This position demands a blend of hands-on technical mastery and strategic thinking to accelerate timelines while maintaining a patient-focused approach.

Requirements

Advanced degree (PhD preferred, or MS) in Chemical Engineering, Biomedical Engineering, Virology, Molecular Biology, or a related field.
8+ years (PhD) or 10+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting.
Deep technical hands-on experience in purification, chromatography, and TFF specifically for viral vectors (Lentivirus preferred)
Strong understanding of GMP manufacturing requirements and CMC strategies for early-phase clinical trials.
Deep knowledge and hands-on experiences in cell and lentiviral vector technologies within the current emerging field
Ability to implement closed-system processes and maximize cost effectiveness
Strong knowledge in engineering modeling and optimization.
Excellent leadership, emotional intelligence, and communication skills; ability to maintain composure and strategic focus during challenging development timelines.
Creative, strategic thinking
Strong troubleshooting skills

Nice To Haves

Preferred experience in developing vector processes tailored for CAR-T generation and systemic delivery
Preferred experience in handling large scale(>50L) purification process.
Mandarin is a plus.

Responsibilities

Design and execute highly efficient purification strategies for lentiviral vectors, specifically optimized for CAR-T applications.
Direct the development and optimization of downstream processes including and not limited to: clarification (depth filtration, centrifugation), chromatography (AEX, SEC, HIC), and Tangential Flow Filtration (TFF) for concentration and diafiltration.
Provide hands-on training as needed.
Direct the translation of bench-scale processes to GMP manufacturing, ensuring seamless technology transfer and providing troubleshooting support during clinical production runs
Lead the execution of study protocols to define operating parameters and performance limits; implement state-of-the-art knowledge management for DSP data.
Communicate the potential for issues and delays along with solutions and mitigation approaches.
In collaboration with the Senior Leaders, CMC Project Manager, Project Leader, and other technical leads identify project acceleration opportunities.
Leverage advanced science and technology to maximize vector recovery, purity, and potency, identifying creative solutions to define unknowns in the viral vector field.
Guide a team of scientists in the execution of project-specific activities, fostering a culture of transparency, scientific rigor, and continuous improvement.
Author and serve as a primary reviewer for technical documents, including development reports, SOPs, and CMC sections for regulatory submissions (IND/IMPD).
Work closely with Upstream Process Development and Analytical Development teams to ensure integrated and holistic process outcomes.
Tech transfer process to/from other Legend sites or CDMOs
Resolve conflict and proactively identify/address performance issues.
Ensure compliance with regulatory requirements.

Benefits

Medical, dental, and vision insurance
401(k) retirement plan with a company match that vests fully on day one
Eight (8) weeks of paid parental leave after just three (3) months of employment
Paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays.
Flexible spending and health savings accounts
Life and AD&D insurance
Short- and long-term disability coverage
Legal assistance
Supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance
Voluntary commuter benefits
Family planning and care resources
Well-being initiatives
Peer-to-peer recognition programs