Principal Scientist, Data Science – AI & Generative AI Systems – R&D DDSAI – Therapeutics Development & Supply (TDS)
About The Position
Johnson & Johnson Innovative Medicine is seeking a Principal Scientist, Data Science for its R&D Data Science organization. The role designs, builds, evaluates, and deploys AI and generative AI systems to accelerate scientific, regulatory, and technical workflows across Therapeutics Development & Supply (TDS). It is a hands-on individual-contributor position working across Product Development, Manufacturing, Clinical Supply Chain, Quality, and Digital and Data Science teams. Applications include scientific and regulatory document authoring, evidence-based response generation, knowledge retrieval and synthesis, technical decision support, and workflow automation. The role aligns solutions with TDS priorities and collaborates with DDSAI AI/ML teams on shared architectures, reusable components, evaluation standards, responsible AI practices, and scalable deployment. The primary locations are Spring House or Malvern, Pennsylvania.
Requirements
- Degree in Engineering, Data Science, Life Sciences, Computer Science, or a related field; an advanced degree is preferred.
- 3–5+ years of hands-on experience building and deploying AI, NLP, or generative AI solutions, including large language models (LLMs).
- Experience in Pharmaceutical Product Development, including Chemistry, Manufacturing and Controls (CMC).
- Strong proficiency in Python.
- Strong communication skills and the ability to explain technical topics to non-technical stakeholders.
Nice To Haves
- Experience with open-source agentic frameworks such as LangGraph, DSPy, or mem0.
- Experience with retrieval-augmented generation, embeddings, vector databases, and model evaluation.
- Exposure to working in regulated environments (GxP).
- Familiarity with responsible AI frameworks, content safety practices, and AI governance in regulated environments.
- Advanced degree in Engineering, Data Science, Life Sciences, Computer Science, or a related field.
Responsibilities
- Design, build, test, and deploy AI solutions for documentation, knowledge retrieval, evidence synthesis, and decision support in the TDS ecosystem.
- Build agentic AI workflows that coordinate models, tools, data, and human review across multi-step scientific and supply chain processes.
- Develop reusable AI capabilities aligned with DDSAI AI/ML architecture and platform standards.
- Translate scientific, regulatory, and operational needs into scalable AI systems for regulated environments.
- Establish evaluation frameworks for LLM systems, including rubrics, traceability, robustness, uncertainty, and usability.
- Apply responsible AI practices, including human-in-the-loop validation, risk assessment, content safety, and governance.
- Maintain software engineering practices including modular design, testing, documentation, and lifecycle management.
- Contribute to best practices for LLM, RAG, and agentic AI systems across DDSAI and TDS.
- Partner with regulatory, quality, CMC, scientific, and technical stakeholders to define use cases, validate outputs, and drive adoption.
- Collaborate with DDSAI AI/ML on infrastructure, architecture, evaluation, and reusable components.
- Communicate system behavior, risks, and tradeoffs to technical and non-technical stakeholders.
Benefits
- Company consolidated retirement plan (pension) and savings plan (401(k)), subject to plan terms.
- Eligibility to participate in the long-term incentive program.
- Vacation: 120 hours per calendar year.
- Sick time: 40 hours per calendar year, with specified higher allowances for employees residing in Colorado or Washington.
- Holiday pay, including floating holidays: 13 days per calendar year.
- Work, Personal and Family Time: up to 40 hours per calendar year.
- Parental Leave: 480 hours within one year of the birth, adoption, or foster care of a child.
- Bereavement Leave: 240 hours for an immediate family member and 40 hours for an extended family member per calendar year.
- Caregiver Leave: 80 hours in a 52-week rolling period.
- Volunteer Leave: 32 hours per calendar year.
- Military Spouse Time-Off: 80 hours per calendar year.
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Principal
