Principal Scientist, Data Science – AI & Generative AI Systems – R&D DDSAI – Therapeutics Development & Supply (TDS)

Johnson & Johnson • Spring House, PA

6d

About The Position

Johnson & Johnson Innovative Medicine is seeking a Principal Scientist, Data Science to design, build, evaluate, and deploy AI and generative AI systems that accelerate scientific, regulatory, and technical workflows across Therapeutics Development & Supply (TDS). This hands-on individual contributor works with Product Development, Manufacturing, Clinical Supply Chain, Quality, and Digital and Data Science teams to deliver LLM applications, agentic workflows, and AI-driven automation for TDS. Example use cases include scientific and regulatory document authoring, evidence-based response generation, knowledge retrieval and synthesis, technical decision support, and workflow automation.

The role aligns with TDS priorities and collaborates with DDSAI AI/ML on shared architectures, reusable components, evaluation standards, responsible AI practices, and scalable deployment. The successful candidate has a strong pharmaceutical CMC development background and develops AI solutions in collaboration with AI/ML teams. The position may be based in Spring House or Malvern, Pennsylvania.

Requirements

• Degree in Engineering, Data Science, Life Sciences, Computer Science, or a related field.
• 3–5+ years of hands-on experience building and deploying AI, NLP, or generative AI solutions, including large language models (LLMs).
• Experience in pharmaceutical product development, including Chemistry, Manufacturing and Controls (CMC).
• Strong proficiency in Python.
• Strong communication skills and ability to explain technical topics to non-technical stakeholders.

Nice To Haves

• Advanced degree.
• Experience with open-source agentic frameworks such as LangGraph, DSPy, or mem0.
• Experience with retrieval-augmented generation, embeddings, vector databases, and model evaluation.
• Exposure to working in regulated environments (GxP).
• Familiarity with responsible AI frameworks, content safety practices, and AI governance in regulated environments.

Responsibilities

• Design, build, test, and deploy AI solutions for documentation, knowledge retrieval, evidence synthesis, and decision support in the TDS ecosystem.
• Build agentic AI workflows that coordinate models, tools, data, and human review across multi-step scientific and supply chain processes.
• Develop reusable AI capabilities aligned with DDSAI AI/ML architecture and platform standards.
• Translate scientific, regulatory, and operational needs into scalable AI systems for regulated environments.
• Establish evaluation frameworks for LLM systems, including rubrics, traceability, robustness, uncertainty, and usability.
• Apply responsible AI practices, including human-in-the-loop validation, risk assessment, content safety, and governance.
• Maintain strong software engineering practices, including modular design, testing, documentation, and lifecycle management.
• Contribute to best practices for LLM, RAG, and agentic AI systems across DDSAI and TDS.
• Partner with regulatory, quality, CMC, scientific, and technical stakeholders to define use cases, validate outputs, and drive adoption.
• Collaborate with DDSAI AI/ML on infrastructure, architecture, evaluation, and reusable components.
• Communicate system behavior, risks, and tradeoffs to technical and non-technical stakeholders.

Benefits

• Participation in the Company’s consolidated retirement plan (pension) and savings plan (401(k)), subject to plan terms.
• Eligibility to participate in the Company’s long-term incentive program.
• Vacation: 120 hours per calendar year.
• Sick time: 40 hours per calendar year, with different amounts for employees residing in Colorado or Washington.
• Holiday pay, including floating holidays: 13 days per calendar year.
• Work, Personal and Family Time: up to 40 hours per calendar year.
• Parental Leave: 480 hours within one year of the birth, adoption, or foster care of a child.
• Bereavement Leave: 240 hours for an immediate family member and 40 hours for an extended family member per calendar year.
• Caregiver Leave: 80 hours in a 52-week rolling period.
• Volunteer Leave: 32 hours per calendar year.
• Military Spouse Time-Off: 80 hours per calendar year.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal