Principal Scientist, Cardiovascular Translational Biomarker

Bristol Myers Squibb • Princeton, NJ

19h • Onsite

About The Position

The Immunology and Cardiovascular Thematic Research Center (ICV TRC) at BMS is one of the fundamental Research units delivering therapeutics to patients. Our mission is to create transformative medicines of tomorrow based on the cutting-edge science of today. We leverage BMS’s internal invention engine that includes industry-leading expertise in small molecule chemistry, protein biotherapeutics, cell therapy, protein degradation, nucleic acids, and other therapeutic modalities. We are seeking a translational scientist with a background in cardiovascular biology to identify and discover novel and existing biomarkers to support the progression of late-discovery programs to early phase clinical trials and beyond. As such, this position will involve a close collaboration with the development organization. The translational scientist may serve as a liaison of discovery to development. The successful candidate will collaborate closely with early discovery team members to drive the progression of programs, which may include assisting the completion of pharmacology studies and guide the selection and analysis of endpoints to support an early translational development plan, including patient segmentation hypotheses. They will be able to apply their knowledge of cardiovascular biology and translational aspects of cardiovascular medicine to establish pharmacodynamic endpoints consistent with mechanism of action, which may involve in vivo, functional-structural analyses and ex vivo or in vitro biochemical or molecular assays, including the development of novel assays. The position may work with human samples or human-relevant systems to test translational hypotheses identified in support of biomarker plan development. This is primarily an on-site, lab-based position but time in lab may be dependent on programmatic needs as discovery programs progress to development, to be determined in collaboration with the manager.

Requirements

• Bachelor’s Degree 8+ years of academic and / or industry experience
• Master’s Degree 6+ years of academic and / or industry experience
• Ph.D. or equivalent advanced degree in the Life Sciences 4+ years of academic and / or industry experience

Nice To Haves

• Ph.D. in Physiology, Pharmacology, Biology, Biochemistry, or a related field with 2+ years of relevant industry experience and 5+ years’ experience after completion of terminal degree, including post-doctoral training.
• PharmD/DVM/MD may be considered with a strong track record of achievement in the basic sciences or drug discovery from hands-on contributions.
• Alternatively, an M.S. in a related field with 5+ years (after completion of degree) relevant industry experience.
• Strong understanding of cardiovascular physiology and modern cardiovascular methodologies (including those that may serve as pharmacodynamic endpoints) employed pre-clinically and clinically
• Includes a strong understanding of imaging biomarkers used in the clinic (eg ultrasound-echocardiography, MRI, and PET)
• An understanding of the considerations for the use of animals in research, with a focus species-specific use, and can articulate and apply 3Rs principles in designing and initiating experiments
• Hands-on experience handling rodents is necessary
• Expertise culturing and making biochemical and/or functional measurements in iPSC-CM, primary cardiac cells, and/or engineered heart tissues is necessary
• Excellent laboratory skills, prioritizing accurate and reproducible work.
• Skill in managing external collaborators and setting clear timelines and expectations
• Must be self-motivated, detail-oriented, collaborative, and able to work effectively in a multidisciplinary, matrixed team environment.

Responsibilities

• Perform studies to define pharmacodynamic biomarkers of response and disease progression, as a member of a discovery team and can investigate and articulate how these biomarkers may translate to the clinic
• Thorough knowledge of experimental design, and a high level of technical laboratory skills (including cell culture of relevant cell lines and primary cells, immunoassays, such as ELISA/MSD, IHC, protein signaling, qPCR technology platforms) together with an ability to interpret results
• Employs technical knowledge and theory to make experimental in-life modifications, when necessary
• Lead studies to completion, including the hands-on analysis of samples internally or directing studies externally through management of CROs.
• Evaluate programs critically and present findings and recommendations to discovery teams and leadership
• Document, critically review, modify experimental approach, if necessary, and present experimental data in a timely manner.
• Collaborate with cross-functional teams by providing timely and actionable study results.
• Provide hands-on training and guidance to develop team members
• Contribute to and author reports, abstracts, and publications.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
• Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
• All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Education Level: Ph.D. or professional degree