Principal Scientist, Translational Computational Biology
About The Position
At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on our patients. RayzeBio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.
Requirements
- BS 8+ years in Biology, Pharmacology, Translational Research, Molecular Biology, or a related discipline.
- MS 6+ years in Biology, Pharmacology, Translational Research, Molecular Biology, or a related discipline.
- PhD 4+ years in Biology, Pharmacology, Translational Research, Molecular Biology, or a related discipline.
Responsibilities
- Lead computational biology strategies supporting discovery and translational research from target identification through clinical development.
- Develop and implement bioinformatics pipelines to analyze genomic, transcriptomic, proteomic, and other multi-omics datasets from preclinical and clinical studies.
- Integrate molecular and clinical data to identify biomarkers, characterize mechanisms of action and resistance, and support patient selection strategies.
- Support Translational Medicine leads in the design and analysis of genomics and other molecular profiling studies using clinical biospecimens, as appropriate, to inform biomarker strategies, patient selection, and clinical development.
- Serve as the computational biology lead on cross-functional project teams, providing scientific leadership across Discovery Biology, Translational Science, and Translational Medicine.
- Design and execute computational analyses supporting target validation, biomarker development, pharmacodynamic assessments, and analysis of clinical genomics and multi-omics datasets to enable clinical translation and patient selection.
- Apply statistical, machine learning, and AI-based approaches to extract biological insights and develop predictive models.
- Establish best practices for computational biology, reproducible analytics, and data integration across the organization.
- Champion the evaluation and adoption of AI-enabled technologies to enhance biological data analysis, knowledge discovery, and scientific workflows.
- Partner with internal and external collaborators to develop scalable computational solutions and support translational research strategies.
- Present findings to multidisciplinary teams and senior leadership and contribute to publications, regulatory documents, and scientific presentations.
- Mentor junior scientists and provide technical leadership in computational biology and data science.
- Applies AI to improve team execution and decision‑making
Benefits
- Medical, pharmacy, dental, and vision care.
- BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
- 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
- flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees))
- 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
- unlimited paid sick time
- up to 2 paid volunteer days per year
- summer hours flexibility
- leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs
- an annual Global Shutdown between Christmas and New Years Day.
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What This Job Offers
Job Type
Full-time
Career Level
Principal
Education Level
Ph.D. or professional degree
