Principal Scientist and Group Leader, Antibody Engineering
About The Position
Genentech’s Department of Antibody Engineering is seeking a visionary Principal Scientist to lead a high-impact laboratory team at the forefront of biotherapeutic innovation. In this role, you will pioneer breakthrough protein technologies that seamlessly bridge molecular developability with optimized biological function to advance our biologics pipeline. Operating in a collaborative and highly interdisciplinary environment, you will develop molecular formats that interrogate complex disease biology, translating exploratory science into transformational medicines for patients.
Requirements
- PhD in biochemistry, chemical biology, structural biology, or a related field.
- Demonstrated expertise in both protein engineering and biology, including a proven track record of applying innovative molecular engineering approaches to resolve complex biological questions or therapeutic challenges.
- Foundational understanding of protein stability and protein-protein interactions along with methods for their characterization.
- Sustained track record of productivity and substantial scientific contributions, evidenced by publications in top-tier peer-reviewed journals, issued patents, and/or notable external scientific presentations.
- Strong collaborative mindset with exceptional written and verbal communication skills and a passion for translating science into drugs.
Nice To Haves
- Prior research experience with antibodies is not essential.
- We encourage applications from candidates with extensive prior experience as well as those coming directly from postdoctoral positions.
Responsibilities
- Direct and manage a bench-focused laboratory team, fostering technical growth, innovative research, and effective execution.
- Advance internal technological capabilities by developing novel methods and predictive assays to de-risk emerging therapeutic formats.
- Define molecular requirements for therapeutic projects and lead cross-functional teams to identify and advance next-generation clinical candidates.
- Drive platform innovation across emerging biotherapeutic mechanisms, potentially including induced proximity, receptor agonism, targeted therapeutics, or antibody-drug conjugates (ADCs).
- Cultivate an inclusive, high-performing lab culture built on curiosity, scientific rigor, and open communication.
- Collaborate closely with multidisciplinary research partners across Discovery Biology, Structural Biology, Translational Science, and Technical Development to integrate biological activity with clinical manufacturability.
Benefits
- Relocation benefits are available for this posting
- A discretionary annual bonus may be available based on individual and Company performance.
- This position also qualifies for the benefits detailed at the link provided below.
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What This Job Offers
Job Type
Full-time
Career Level
Principal
Education Level
Ph.D. or professional degree
