Raven StealthCo- Principal Scientist, Analytical Chemistry

Raven•Boston, MA

55d•Onsite

About The Position

We are a well-funded, stealth-mode biotechnology company developing next-generation oligonucleotide-based therapeutics for a high-value disease area with significant unmet medical need. The company is headquartered in Cambridge, Massachusetts, and was incubated and funded by a leading life sciences venture group. We are led by an experienced founder-CEO with a strong track record of building and scaling biotechnology companies. The company has completed a robust incubation process and is backed by a substantial seed investment. Our disease focus represents a large, multi-billion-dollar market with significant room for improvement over existing therapies. We are building a first-of-its-kind integrated platform leveraging tailored oligonucleotide chemistry, targeted delivery, and state-of-the-art analytics to develop first-in-class and best-in-class therapeutics. The company is currently operating in stealth mode as we commit to building and scaling quickly to create transformational medicines with significant market potential. Our platform is designed to address multiple disease indications at scale, including both primary and adjacent therapeutic areas. The company is in the discovery stage and will invest heavily in its emerging platform for oligonucleotide delivery. Our disease focus offers strong translatability from animal models to humans, which provides a potentially rapid and efficient path to the clinic. Given the company's recent funding and commitment to building a first-class platform with clear therapeutic targets and indications, we are recruiting a Principal Scientist, Analytical Chemistry. This individual will be responsible for developing analytical methods and characterizing our oligonucleotide conjugates for our targeted delivery platform.

Requirements

PhD. in chemistry or related discipline with 5+ years of experience working with oligonucleotide therapeutics (siRNA, ASOs, etc.) in the biopharmaceutical industry; or BS/MS with 10+ years
Ideal candidate will have experience analyzing peptide-, protein-, or antibody-oligonucleotide conjugates, effectively operating in a cross-functional, collaborative environment
Adept in state-of-the-art analytical methods (SEC, IEX, RP-HPLC, MS, etc.) to characterize oligonucleotide conjugates
Experience in (bio)analytical assays to determine pharmacokinetic, distribution, and PD profiles of oligonucleotide therapeutics is a plus
Must be an effective communicator and proven team-player, with the ability to operate independently in a laboratory setting
Highly collaborative, intellectually curious, driven, trustworthy, humble, and who brings an adaptable and flexible working style
Highly organized, thoughtful, and bring sound judgement and technical decision-making abilities
Highly nuanced in terms of their interpersonal style and able to lead and work effectively within a highly collaborative, entrepreneurial, and fast-paced start-up environment
Ph.D. and/or BS/MS in a relevant discipline such as chemistry or analytical sciences
Personal characteristics, leadership abilities, technical fluency, creativity, work ethic, behavioral flexibility, and demonstrated accomplishments will serve as key components in the evaluation of candidates.

Nice To Haves

While demonstrating creativity to contribute to the development of novel delivery systems, this individual must also be process- and detail-oriented to ensure proper release of high-quality oligonucleotide material for in vivo testing

Responsibilities

Define and implement reproducible analytical protocols to characterize oligonucleotides for biological evaluation in our targeted delivery platform
Develop and implement QC methods to determine purity, composition, and concentration of oligonucleotides and conjugates using a toolbox of analytical methods (HPLC, MS, (bio)analytical assays, etc.)
Develop and implement analytical methods (e.g., MS) to determine drug-to-conjugate ratios of antibody-oligonucleotide conjugates
Develop and implement analytical methods to determine in vitro stability (e.g., serum stability) of oligonucleotides and conjugates
In conjunction with the biology group, assist in development and implementation of analytical methods to determine pharmacokinetics and distribution of oligonucleotides and conjugates in vivo
Assist in internal lab build, procuring and utilizing analytical equipment to characterize oligonucleotides and antibody/peptide-oligonucleotide conjugates
Assist conjugation scientists in developing methods (SEC, IEX, etc.) to purify oligonucleotide conjugates