Principal Research Scientist I

AbbVie•North Chicago, IL

1d•$124,500 - $236,500

About The Position

The Translational Safety Pharmacology department provides rigorous in vitro and in vivo safety assessments and fit-for-purpose assay development to enable informed discovery and development decisions. Cardiovascular safety pharmacology is central to advancing safe, high-quality medicines. The Principal Research Scientist serves as the in vivo cardiovascular safety pharmacology subject-matter leader, providing scientific and strategic leadership across rodent, canine, and nonhuman-primate models. The role leads the design, execution, interpretation, and reporting of cardiovascular safety studies; advances GLP and regulatory readiness; and partners across a matrixed organization to deliver reproducible, decision-ready data.

Requirements

PhD in physiology, pharmacology, toxicology, or a related field.
10+ years of relevant experience in cardiovascular biology, safety pharmacology, or a closely related discipline.
Demonstrated cardiovascular biology and safety pharmacology expertise, including the ability to design, execute, interpret, and report in vivo cardiovascular studies.
Experience with rodent and large-animal studies, including canine and nonhuman-primate models.
Experience authoring and implementing SOPs, with working knowledge of GLP, quality systems, and regulatory-ready documentation.
Strong written and verbal scientific communication skills.
Demonstrated ability to lead in a matrixed environment, apply critical thinking, troubleshoot complex study issues, and manage multiple priorities effectively.
At least one year of previous people management experience.

Responsibilities

Lead the design, execution, quality, interpretation, and reporting of in vivo cardiovascular safety pharmacology studies across rodent, canine, and nonhuman-primate models.
Provide scientific leadership for cardiovascular assessments, including hemodynamics, ECG and electrophysiology, pressure-volume loops, echocardiography, vascular reactivity, thrombosis, and relevant disease models.
Develop, optimize, validate, and implement fit-for-purpose cardiovascular assays and models; author and implement SOPs that support quality, consistency, and regulatory readiness.
Champion data quality, reproducibility, and scientifically sound interpretation; mentor scientists; communicate study strategy, results, and risk assessments to senior leadership, cross-functional stakeholders, and regulatory-facing teams; and advance cardiovascular safety pharmacology capabilities, workflows, and technologies.
Manage team members directly and indirectly in a matrixed environment to help plan, coordinate, and prioritize studies.